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Cell signaling
Estrogen & other Nuclear Receptors
PPAR

PPAR

PPARs are nuclear receptors. PPAR signaling regulates genes involved in lipid metabolism, glucose homeostasis, and inflammation, playing a crucial role in metabolic diseases and energy balance. Researchers can make big savings on Hello Bio's PPAR inhibitors & activators, our prices are around 25-50% less than other suppliers.

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PPAR

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FH 535 (HB0288)

Description:
Wnt/β-catenin inhibitor and PPARγ/δ antagonist.

Purity:
>99%

Pack:
50mg

Price:

$521

Qty:

Supporting Docs Add to Favorites
Telmisartan (HB2558)

Description:
AT₁ antagonist and PPARγ partial agonist

Purity:
>98%

Pack:
10mg

Price:

$42

Qty:

Pack:
50mg

Price:

$106

Qty:

Supporting Docs Add to Favorites

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      1. Fluorescent ligands(20)
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Target
1. Receptors & Transporters(362)
  1. G protein coupled receptors(249)
    1. Metabotropic glutamate(47)
      1. Group I (mGlu₅, mGlu₁)(21)
      2. Group II (mGlu₃, mGlu₂)(9)
      3. Group III (mGlu₄, mGlu₆, mGlu₇, mGlu₈)(11)
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      1. A₁(3)
      2. A₂(6)
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    3. Adrenoceptors(10)
      1. α(4)
        α₁(2)
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    4. ACh muscarinic(10)
      1. Non-selective(2)
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    9. DREADD(22)
    10. Endothelin(2)
      1. Endothelin B(1)
      2. Non-selective(1)
    11. Estrogen (GPER / GPR30)(1)
    12. GABA-B(9)
      1. Miscellaneous(1)
    13. Histamine(9)
      1. H₁(2)
      2. H₂(2)
      3. Non-selective(1)
    14. Leukotriene(1)
      1. LTD4(1)
    15. Lysophosphatidic Acid(1)
      1. Non-selective(1)
    16. Opioid(5)
    17. Peptide Receptors(39)
      1. AdipoR(4)
      2. Angiotensin(3)
      3. Cholecystokinin (CCK)(1)
        CCK2(1)
      4. Endothelin(6)
        ETA(1)
        ETB(3)
        Non-selective(2)
      5. Formyl peptide(1)
      6. Glucagon and related(3)
        GLP-1(1)
      7. Ghrelin(1)
      8. Mas-Related G Protein-Coupled Receptors (MRGPRS)(1)
      9. Motilin(1)
      10. Neuropeptide S (NPSR)(1)
      11. Neuropeptide Y (NPY)(2)
      12. Orexin(6)
        OX1(4)
        OX2(5)
      13. Oxytocin(1)
      14. Protease-Activated Receptors (PAR)(4)
      15. Somatostatin (SST)(1)
      16. Tachykinin(1)
      17. Galanin(2)
    18. Purinergic: P2Y(3)
      1. P2Y₆(1)
      2. P2Y₁₂(1)
    19. 5-HT(45)
      1. 5-HT₁(17)
        5-HT_1A(8)
        5-HT_1B(5)
        5-HT_1C(1)
        5-HT_1D(5)
        5-HT_1E(1)
        5-HT_1F(2)
      2. 5-HT₂(19)
        5-HT_2A(11)
        5-HT_2B(3)
        5-HT_2C(2)
        Non-selective(2)
      3. 5-HT₄(3)
      4. 5-HT₆(3)
      5. 5-HT₇(1)
      6. Non-selective(1)
      7. Other(3)
    20. Sphingosine-1-phosphate(2)
    21. Smo(4)
  2. Enzyme-linked (Catalytic)(36)
    1. RSTKs(8)
      1. TGF-β(7)
      2. BMP/Activin(2)
    2. RTK(17)
      1. CSF1R (Colony stimulating factor 1 receptor)(3)
      2. FGFR(2)
      3. VEGFR(1)
      4. Trk receptors(9)
      5. Eph(1)
    3. Toll-like receptor(6)
      1. TLR2(1)
      2. TLR7(3)
  3. Nuclear Receptors(43)
    1. Aryl hydrocarbon receptor(1)
    2. Estrogen and related(16)
      1. Estrogen-α(2)
      2. Estrogen-β(2)
      3. Non-selective(12)
    3. Liver X and farnesoid X receptors (LXR/FXR)(2)
    4. Glucocorticoid(5)
    5. Mineralocorticoid(3)
    6. Other(6)
      1. DAF-12(1)
      2. Ecdysone receptor(4)
    7. PPAR(9)
      1. PPARγ(9)
      2. PPARδ(1)
    8. Progesterone(1)
    9. Retinoic Acid (RAR)(1)
  4. Transporters(36)
    1. Cannabinoid(1)
    2. Dopamine (DAT)(1)
    3. GABA uptake & transport(5)
    4. Glutamate uptake & transport(5)
    5. Glycine(2)
    6. Monoamine(2)
      1. VMAT2(1)
    7. Multidrug Transporters(1)
    8. Na⁺/Ca²⁺ exchangers(2)
    9. Na⁺/H⁺ exchangers(1)
    10. 5-HT uptake & transport(15)
    11. SGLT(1)
      1. SGLT-2(1)
    12. Norepinephrine (NET)(2)
  5. Other(2)
    1. σ(1)
      1. σ1(1)
    2. Imidazoline Receptors(1)
      1. Imidazoline I₂(1)
2. Ion channels(238)
  1. Ligand-gated ion channel(126)
    1. Ionotropic glutamate receptors(84)
      1. AMPA(27)
      2. NMDA(40)
        GluN1(3)
        GluN2(5)
        GluN2A(2)
        GluN2B(2)
        GluN2C(4)
        GluN2D(4)
      3. Kainate(16)
      4. Miscellaneous(9)
      5. Non-selective ionotropic glutamate(2)
    2. Purinergic: P2X(7)
      1. P2X₄(1)
      2. P2X₇(1)
      3. Non-selective(3)
    3. Acid-sensing (proton-gated) (ASICs)(1)
    4. GABA-A(21)
    5. IP₃(2)
    6. Glycine(3)
    7. Nicotinic AcH(8)
      1. α3β4(1)
      2. α4β2(1)
      3. α7(4)
      4. Non-selective(2)
    8. PSEMS(4)
    9. 5-HT₃(1)
  2. Voltage-gated ion channel(107)
    1. Sodium Channels(17)
    2. Potassium Channels(48)
      1. Voltage-gated (K_v)(14)
      2. Two-P(7)
      3. BK channels(3)
      4. Calcium activated (K_Ca)(14)
      5. Inwardly rectifying (K_ir)(10)
    3. Ryanodine receptor(1)
      1. Non-selective(1)
    4. Calcium Channels(20)
      1. Ca_v1.x (L-type) (7)
      2. Ca_v2.x(7)
      3. Ca_v3.x (T-type)(3)
    5. Cyclic nucleotide-regulated channels(2)
    6. TRP(21)
      1. TRPA(3)
      2. TRPC(2)
        TRPC6(1)
      3. TRPM(4)
      4. TRPV(10)
  3. Other(9)
    1. Ionophores(3)
    2. Piezo(6)
3. Enzymes(385)
  1. ATPase / GTPase(16)
    1. Ca²⁺-ATPase (SERCA)(5)
    2. H⁺-ATPase(5)
    3. Myosin ATPase(3)
      1. Na⁺/K⁺ ATPase(2)
  2. Cyclase(5)
    1. Adenylyl cyclase(2)
    2. Guanylyl cyclase(3)
  3. Deacetylase(19)
    1. Histone deacetylase (HDAC)(19)
      1. Non-selective(2)
      2. Sirtuin(2)
        SIRT2(1)
        Sir2P(1)
  4. Deaminase(2)
    1. XMP aminase(1)
  5. Demethylase(4)
    1. Histone demethylase(4)
  6. Dehydrogenase(3)
    1. Aldehyde Dehydrogenase(1)
    2. Monophosphatase dehydrogenase(1)
  7. Esterase(10)
    1. Lipase(1)
    2. Phospholipase(3)
  8. Glycosylase(2)
    1. Glucosidase(2)
      1. α(2)
  9. Hydrolase(4)
    1. FAAH(2)
    2. GCH1 (GTP cyclohydrolase I)(1)
    3. Helicase(1)
  10. Hydroxylase(5)
    1. Tryptophan hydroxylase(1)
    2. Tyrosine Hydroxylase(3)
  11. Isomerase(11)
    1. DNA Topoisomerase(11)
      1. DNA Gyrase(1)
      2. Type 1(3)
      3. Type 2(6)
  12. Kinase(143)
    1. Abl(1)
    2. Akt / PKB(5)
    3. AMPK(5)
    4. Aurora kinase(5)
      1. Aurora Kinase A(2)
      2. Aurora Kinase B(1)
      3. Non-selective(1)
    5. BTK(1)
    6. CAM Kinase II(4)
    7. Casein kinase(4)
    8. CDK(3)
      1. CDK1(3)
      2. CDK2(1)
      3. Non-selective(3)
    9. c-Src(5)
    10. DYRK(1)
    11. ERK(2)
      1. ERK2 / MAPK1(1)
    12. GRK(4)
      1. Non-selective(1)
    13. GSK-3(8)
    14. Hexokinase(1)
    15. JAK(5)
    16. MAPK(15)
      1. p38 MAPK(8)
      2. MEK(5)
        MEK1(1)
      3. JNK(2)
    17. MAPKAP(1)
      1. MAPKAP2(1)
    18. mTOR(5)
    19. Myosin light chain kinase (MLCK)(1)
    20. Non-selective(2)
    21. PERK(1)
    22. PKA(5)
    23. PKC(32)
    24. PKG(2)
    25. PI-3K(6)
    26. Protein-serine/threonine kinase(3)
    27. Protein-tyrosine kinase(2)
      1. Non-selective(2)
    28. RIP kinase(3)
      1. RIP1(2)
    29. ROCK(7)
    30. RSK(1)
    31. Sphingosine kinase(1)
    32. Syk(1)
    33. Raf(2)
      1. B-Raf(2)
      2. c-RAF(2)
  13. Ligase(1)
    1. Ubiquitin/Ubl E2 conjugating(1)
      1. Ub-conjugating enzyme (E2) complex(1)
  14. Oxidase(4)
    1. Monoamine Oxidase(2)
      1. Non-selective(2)
    2. Tyrosinase(1)
  15. Oxygenase(8)
    1. COX(6)
      1. COX-2(2)
    2. 5-lipoxygenase(2)
  16. Phosphodiesterase(10)
    1. PDE1(4)
    2. PDE4(4)
    3. Non-selective(2)
    4. Sphingomyelinase(1)
      1. N-Smase(1)
  17. Phosphatase(25)
    1. Alkaline phosphatase(2)
    2. Protein-tyrosine phosphatase(7)
      1. PTP1B(1)
  18. Polymerase(9)
    1. DNA/RNA(5)
    2. Tankyrase (TNKS)(2)
    3. Telomerase(2)
  19. Protease / Peptidase(55)
    1. ACE2(1)
    2. Aminopeptidase(1)
    3. Angiotensin-Converting Enzyme (ACE)(1)
    4. Aspartic protease(1)
    5. Calpains(1)
    6. Caspase(11)
      1. Broad(2)
    7. Cathepsin(1)
      1. Cathepsin B(1)
    8. Deubiquitinating Enzymes(1)
      1. Ubiquitin C-terminal hydrolase(1)
    9. Dipeptidyl-peptidase 4(1)
    10. Elastase(1)
    11. Matrix metalloprotease(2)
      1. MMP-1(1)
    12. Methionine aminopeptidase-2(1)
    13. Other(4)
    14. Protease inhibitors and inhibitor cocktails(11)
    15. Prolyl endopeptidase (PREP)(1)
    16. Proteasome(12)
    17. Serine/cysteine protease(2)
    18. Secretase(4)
      1. γ(4)
  20. Reductase(3)
    1. Aldose reductase(1)
    2. NADH ubiquinone oxidoreductase(1)
  21. Synthase(14)
    1. HMG-CoA synthase(1)
  22. Transferase(36)
    1. ACAT(5)
    2. DGAT(2)
    3. DNA methyltransferase (DNMT)(4)
    4. Histone acetyltransferase (HAT)(1)
    5. Histone methyltransferase (HMTs)(6)
    6. Phosphorylase(1)
    7. Protein prenyltransferases(6)
    8. PORCN(4)
    9. Tankyrase (TNKS)(1)
4. Proteins - Other(59)
  1. Actin(8)
  2. Choline ester transfer protein (CETP)(1)
  3. GAPDH(1)
  4. GFAP(4)
  5. GFP(3)
  6. Histones(5)
    1. Bromodomain(4)
  7. HSP60(1)
  8. MAP2(2)
  9. mCherry(1)
  10. NeuN(3)
  11. Neurofilament L(1)
  12. Neurofilament M(1)
  13. N-WASP(1)
  14. Plasminogen PAI-1(1)
  15. STAT(5)
  16. Tubulin(4)
    1. βIII-tubulin(2)
    2. β-tubulin(1)
  17. Myelin basic protein(1)
  18. c-Fos(1)
  19. IBA1(1)
  20. Alpha-synuclein(1)
  21. VLP1(1)
Cell signaling
1. PI3K/Akt/mTOR(17)
  1. Akt(5)
  2. PI3K(6)
  3. mTOR(5)
2. TGF-Beta/SMAD/ROCK(16)
  1. Bcr-Abl(1)
  2. ROCK(7)
  3. TGF-Beta/ SMAD(8)
3. MAPK(19)
  1. p38 MAPK(9)
  2. MEK(5)
  3. ERK(2)
    1. ERK2 / MAPK1(1)
  4. JNK(2)
  5. Raf(1)
4. Estrogen & other Nuclear Receptors(19)
  1. Aryl Hydrocarbon Receptors(1)
  2. Estrogen Receptor signaling(16)
    1. Estrogen-α(2)
    2. Estrogen-β(2)
    3. Non-selective(12)
  3. Estrogen GPER receptors(1)
  4. PPAR(2)
5. Wnt/Beta-Catenin signaling(10)
  1. β-catenin(8)
6. Anticancer(15)
  1. Cytotoxic(7)
7. Anti-oxidant(10)
  1. Mitochondrial complex II(2)
8. Cyclic nucleotide and related(44)
  1. Adenylyl cyclase (AC)(2)
  2. cAMP(3)
  3. Guanyl cyclase (GC)(2)
  4. Inositol trisphosphate (IP3)(2)
  5. PKA(5)
  6. PKC(31)
9. Ca²⁺ signaling(29)
10. Gap channels (gap junctions)(3)
11. G protein(6)
  1. Small monomeric GTPase(2)
  2. G Protein (Heterotrimeric)(4)
12. Heatshock proteins(3)
  1. HSP90(3)
13. Hedgehog signaling(10)
14. Immune Checkpoint(3)
15. Lipid signaling(1)
16. Notch(4)
17. Transcription factors(9)
  1. HIF(1)
  2. NFAT(3)
  3. NGF(1)
  4. Stats(4)
Cell process
1. COVID-19 Research(191)
  1. Compound repurposing(36)
  2. Virus attachment / entry(10)
    1. TMPRSS2(1)
    2. ACE2(3)
    3. Endocytosis(6)
  3. Virus replication, transcription & maturation(16)
  4. Cytokine Storm / Immune response signaling(78)
    1. Angiotensin related(3)
    2. Cytokines, chemokines & NF-κB/I-κB(20)
      1. Chemokine Receptors(2)
      2. Cytokine Stimulation/ Production(10)
      3. NF-κB / IκB(8)
    3. Inflammasomes(6)
    4. JAK/STAT(9)
    5. MAPK Signaling(18)
      1. p38 MAPK(8)
      2. MEK(5)
      3. ERK(2)
        ERK2 / MAPK1(1)
      4. JNK(2)
      5. Raf(1)
    6. PI3K/Akt/mTOR(15)
      1. Akt(4)
      2. PI3K(6)
      3. mTOR(5)
    7. Protease-Activated Receptors(3)
    8. TLR (Toll-like receptors) signaling(6)
      1. TLR2(1)
      2. TLR7(3)
  5. Organoids(13)
  6. Cell culture reagents & buffers(44)
    1. Selection Antibiotics(8)
    2. Protease inhibitor cocktails and inhibitors(12)
  7. Cell stains, viability & proliferation(13)
  8. CRISPR/ Gene editing(13)
2. Apoptosis & cell cycle(48)
  1. Caspase(11)
  2. Inducers(13)
  3. p53(2)
  4. PARP(4)
    1. PARP-1(2)
    2. Non-selective(1)
  5. RIP kinase(1)
  6. Stains(13)
3. Cell Metabolism(75)
  1. Autophagy(11)
  2. Amyloid-β(12)
  3. Bioactive metabolites(3)
  4. DNA / RNA & protein synthesis(34)
    1. Genome editing / engineering(9)
  5. Oxidative Phosphorylation(5)
  6. Ubiquitin-proteasome system (UPS) (12)
4. Cytoskeleton and Extracellular Matrix(35)
  1. Actin(7)
  2. Matrix Metalloproteases (MMP)(3)
  3. Microtubule(5)
  4. ROCK (Rho-kinase)(7)
5. Immunology & Inflammation(176)
  1. Antivirals / Antibiotics / immunomodulators(143)
    1. Antibiotics(81)
    2. Antimicrobials(9)
    3. Antivirals(28)
      1. COVID-19/SARS-CoV-2 related(19)
    4. Immunosupressants / immunomodulators(10)
    5. Mycotoxin(4)
    6. T-cell Related(9)
  2. Cytokines, chemokines & NF-κB/I-κB(23)
    1. Chemokine Receptors(3)
    2. Cytokine Stimulation/ Production(10)
    3. JNK(2)
    4. NF-κB / IκB(8)
  3. Inflammasome(6)
  4. JAK/STAT(9)
  5. TLR (Toll-like receptors)(6)
    1. TLR2(1)
    2. TLR7(3)
    3. Non-selective(2)
6. Oxidative Stress(7)
  1. ROS(3)
  2. NOS(4)
7. Stem cells(112)
  1. Dedifferentiation(6)
  2. Differentiation(59)
    1. iPSCs & ESCs(18)
    2. Mesenchymal Stem cells (MSCs)(11)
    3. Neural Stem Cells (NSCs)(30)
      1. Neurotrophins(5)
  3. Organoids(14)
  4. Proliferation, self-renewal, maintenance(29)
  5. Reprogramming(22)
  6. Stem cell signaling(20)
8. Epigenetics(4)

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