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Cell process
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TLR (Toll-like receptors) signaling
TLR7

TLR7

3 Items

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TLR7

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Gardiquimod (HB3915)

Description:
Selective toll-like receptor 7 (TLR7) agonist

Purity:
>98%

Pack:
25mg

Price:

$258

Qty:

Supporting Docs Add to Favorites
Imiquimod (HB3109)

1 Review
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Description:
Toll-like receptor 7 (TLR7) agonist

Purity:
>98%

Pack:
100mg

Price:

$91

Qty:

Pack:
250mg

Price:

$179

Qty:

Supporting Docs Add to Favorites
Imiquimod hydrochloride (water soluble) (HB8528)

Description:

Water soluble Toll-like receptor 7 (TLR7) agonist. Stimulates cytokine production.

Purity:
>98%

Pack:
5mg

Price:

$29

Qty:

Pack:
50mg

Price:

$52

Qty:

Pack:
100mg

Price:

$77

Qty:

Pack:
250mg

Price:

$147

Qty:

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Type
1. Antibodies(56)
  1. Primary antibodies(42)
    1. Monoclonals(23)
    2. Polyclonals(19)
    3. Loading controls(4)
    4. Neural Markers(27)
      1. Neuronal Markers(19)
        GABAergic neurons(5)
        Dopaminergic neurons(3)
        Noradrenergic neurons(1)
        General neuronal markers(10)
      2. Glial Markers(5)
        Astrocyte markers(4)
        Microglial Markers(1)
  2. Secondary antibodies(14)
    1. Biotin conjugated(2)
2. Biochemicals & small molecules(1083)
  1. Agonists & activators(261)
  2. Antagonists & inhibitors(719)
3. Caged compounds(4)
4. Chemogenetics(33)
  1. DREADDs(22)
  2. CATKLAMP(4)
5. Imaging, dyes, stains & labels(134)
  1. Antibody and Protein Labeling Kits(2)
  2. Chemiluminescence(2)
  3. Fluorescence Imaging(73)
    1. Fluorescent Dyes / fluorophores(18)
      1. Janelia Fluor® Dyes(18)
        Amine (NHS)-Reactive(2)
        Click-Reactive (click chemistry)(2)
        Free Acid(2)
        Conjugation kits(2)
        Janelia Fluor® Streptavidin conjugates(3)
    2. DNA fluorescent stains(12)
    3. Fluorescent probes & ligands(29)
      1. Fluorescent ligands(20)
        CellAura Fluorescent GPCR ligands(13)
      2. Actin(2)
    4. Cell viability & proliferation(19)
    5. Tyramide Signal Amplification (TSA)(9)
  4. IHC, stains/ counterstains, histology(14)
    1. Counterstains(8)
    2. Special stains(4)
  5. Ion indicators, ionophores & chelators(21)
  6. Labels & stains(28)
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  8. Streptavidin and conjugates(5)
6. Proteins & peptides(127)
  1. Cytokines, Chemokines and Growth factors(68)
    1. Neurotrophins and receptors(68)
      1. BDNF(3)
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      5. GDNF(7)
      6. Glia Maturation Factor(5)
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      11. Neuritin(2)
      12. Neuropilin(3)
      13. Neurotrophic factors(4)
      14. Persephin(2)
      15. Pigment Epithelium-Derived Factor(3)
      16. Pleiotrophin(2)
      17. Other Neurotrophins(6)
  2. Antimicrobial peptides(9)
  3. Neuropeptides(17)
7. Antibiotics(82)
  1. Selection Antibiotics(8)
8. Reagents & Buffers(106)
Target
1. Receptors & Transporters(362)
  1. G protein coupled receptors(249)
    1. Metabotropic glutamate(47)
      1. Group I (mGlu₅, mGlu₁)(21)
      2. Group II (mGlu₃, mGlu₂)(9)
      3. Group III (mGlu₄, mGlu₆, mGlu₇, mGlu₈)(11)
      4. Miscellaneous(5)
    2. Adenosine(18)
      1. A₁(3)
      2. A₂(6)
      3. A₃(3)
      4. Non-selective(6)
    3. Adrenoceptors(10)
      1. α(4)
        α₁(2)
        α₂(1)
        Non-selective(2)
    4. ACh muscarinic(10)
      1. Non-selective(2)
    5. Bradykinin(1)
      1. B₂(1)
    6. Cannabinoid(3)
      1. CB₁(3)
    7. Chemokine(4)
      1. CCR5(1)
    8. Dopamine(37)
      1. D1-like(8)
        D₁(6)
        D₅(1)
      2. D2-like(21)
        D₂(10)
        D₃(3)
        D₄(2)
      3. Dopaminergic related(1)
      4. Non-selective(8)
    9. DREADD(22)
    10. Endothelin(2)
      1. Endothelin B(1)
      2. Non-selective(1)
    11. Estrogen (GPER / GPR30)(1)
    12. GABA-B(9)
      1. Miscellaneous(1)
    13. Histamine(9)
      1. H₁(2)
      2. H₂(2)
      3. Non-selective(1)
    14. Leukotriene(1)
      1. LTD4(1)
    15. Lysophosphatidic Acid(1)
      1. Non-selective(1)
    16. Opioid(5)
    17. Peptide Receptors(39)
      1. AdipoR(4)
      2. Angiotensin(3)
      3. Cholecystokinin (CCK)(1)
        CCK2(1)
      4. Endothelin(6)
        ETA(1)
        ETB(3)
        Non-selective(2)
      5. Formyl peptide(1)
      6. Glucagon and related(3)
        GLP-1(1)
      7. Ghrelin(1)
      8. Mas-Related G Protein-Coupled Receptors (MRGPRS)(1)
      9. Motilin(1)
      10. Neuropeptide S (NPSR)(1)
      11. Neuropeptide Y (NPY)(2)
      12. Orexin(6)
        OX1(4)
        OX2(5)
      13. Oxytocin(1)
      14. Protease-Activated Receptors (PAR)(4)
      15. Somatostatin (SST)(1)
      16. Tachykinin(1)
      17. Galanin(2)
    18. Purinergic: P2Y(3)
      1. P2Y₆(1)
      2. P2Y₁₂(1)
    19. 5-HT(45)
      1. 5-HT₁(17)
        5-HT_1A(8)
        5-HT_1B(5)
        5-HT_1C(1)
        5-HT_1D(5)
        5-HT_1E(1)
        5-HT_1F(2)
      2. 5-HT₂(19)
        5-HT_2A(11)
        5-HT_2B(3)
        5-HT_2C(2)
        Non-selective(2)
      3. 5-HT₄(3)
      4. 5-HT₆(3)
      5. 5-HT₇(1)
      6. Non-selective(1)
      7. Other(3)
    20. Sphingosine-1-phosphate(2)
    21. Smo(4)
  2. Enzyme-linked (Catalytic)(36)
    1. RSTKs(8)
      1. TGF-β(7)
      2. BMP/Activin(2)
    2. RTK(17)
      1. CSF1R (Colony stimulating factor 1 receptor)(3)
      2. FGFR(2)
      3. VEGFR(1)
      4. Trk receptors(9)
      5. Eph(1)
    3. Toll-like receptor(6)
      1. TLR2(1)
      2. TLR7(3)
  3. Nuclear Receptors(43)
    1. Aryl hydrocarbon receptor(1)
    2. Estrogen and related(16)
      1. Estrogen-α(2)
      2. Estrogen-β(2)
      3. Non-selective(12)
    3. Liver X and farnesoid X receptors (LXR/FXR)(2)
    4. Glucocorticoid(5)
    5. Mineralocorticoid(3)
    6. Other(6)
      1. DAF-12(1)
      2. Ecdysone receptor(4)
    7. PPAR(9)
      1. PPARγ(9)
      2. PPARδ(1)
    8. Progesterone(1)
    9. Retinoic Acid (RAR)(1)
  4. Transporters(36)
    1. Cannabinoid(1)
    2. Dopamine (DAT)(1)
    3. GABA uptake & transport(5)
    4. Glutamate uptake & transport(5)
    5. Glycine(2)
    6. Monoamine(2)
      1. VMAT2(1)
    7. Multidrug Transporters(1)
    8. Na⁺/Ca²⁺ exchangers(2)
    9. Na⁺/H⁺ exchangers(1)
    10. 5-HT uptake & transport(15)
    11. SGLT(1)
      1. SGLT-2(1)
    12. Norepinephrine (NET)(2)
  5. Other(2)
    1. σ(1)
      1. σ1(1)
    2. Imidazoline Receptors(1)
      1. Imidazoline I₂(1)
2. Ion channels(238)
  1. Ligand-gated ion channel(126)
    1. Ionotropic glutamate receptors(84)
      1. AMPA(27)
      2. NMDA(40)
        GluN1(3)
        GluN2(5)
        GluN2A(2)
        GluN2B(2)
        GluN2C(4)
        GluN2D(4)
      3. Kainate(16)
      4. Miscellaneous(9)
      5. Non-selective ionotropic glutamate(2)
    2. Purinergic: P2X(7)
      1. P2X₄(1)
      2. P2X₇(1)
      3. Non-selective(3)
    3. Acid-sensing (proton-gated) (ASICs)(1)
    4. GABA-A(21)
    5. IP₃(2)
    6. Glycine(3)
    7. Nicotinic AcH(8)
      1. α3β4(1)
      2. α4β2(1)
      3. α7(4)
      4. Non-selective(2)
    8. PSEMS(4)
    9. 5-HT₃(1)
  2. Voltage-gated ion channel(107)
    1. Sodium Channels(17)
    2. Potassium Channels(48)
      1. Voltage-gated (K_v)(14)
      2. Two-P(7)
      3. BK channels(3)
      4. Calcium activated (K_Ca)(14)
      5. Inwardly rectifying (K_ir)(10)
    3. Ryanodine receptor(1)
      1. Non-selective(1)
    4. Calcium Channels(20)
      1. Ca_v1.x (L-type) (7)
      2. Ca_v2.x(7)
      3. Ca_v3.x (T-type)(3)
    5. Cyclic nucleotide-regulated channels(2)
    6. TRP(21)
      1. TRPA(3)
      2. TRPC(2)
        TRPC6(1)
      3. TRPM(4)
      4. TRPV(10)
  3. Other(9)
    1. Ionophores(3)
    2. Piezo(6)
3. Enzymes(385)
  1. ATPase / GTPase(16)
    1. Ca²⁺-ATPase (SERCA)(5)
    2. H⁺-ATPase(5)
    3. Myosin ATPase(3)
      1. Na⁺/K⁺ ATPase(2)
  2. Cyclase(5)
    1. Adenylyl cyclase(2)
    2. Guanylyl cyclase(3)
  3. Deacetylase(19)
    1. Histone deacetylase (HDAC)(19)
      1. Non-selective(2)
      2. Sirtuin(2)
        SIRT2(1)
        Sir2P(1)
  4. Deaminase(2)
    1. XMP aminase(1)
  5. Demethylase(4)
    1. Histone demethylase(4)
  6. Dehydrogenase(3)
    1. Aldehyde Dehydrogenase(1)
    2. Monophosphatase dehydrogenase(1)
  7. Esterase(10)
    1. Lipase(1)
    2. Phospholipase(3)
  8. Glycosylase(2)
    1. Glucosidase(2)
      1. α(2)
  9. Hydrolase(4)
    1. FAAH(2)
    2. GCH1 (GTP cyclohydrolase I)(1)
    3. Helicase(1)
  10. Hydroxylase(5)
    1. Tryptophan hydroxylase(1)
    2. Tyrosine Hydroxylase(3)
  11. Isomerase(11)
    1. DNA Topoisomerase(11)
      1. DNA Gyrase(1)
      2. Type 1(3)
      3. Type 2(6)
  12. Kinase(143)
    1. Abl(1)
    2. Akt / PKB(5)
    3. AMPK(5)
    4. Aurora kinase(5)
      1. Aurora Kinase A(2)
      2. Aurora Kinase B(1)
      3. Non-selective(1)
    5. BTK(1)
    6. CAM Kinase II(4)
    7. Casein kinase(4)
    8. CDK(3)
      1. CDK1(3)
      2. CDK2(1)
      3. Non-selective(3)
    9. c-Src(5)
    10. DYRK(1)
    11. ERK(2)
      1. ERK2 / MAPK1(1)
    12. GRK(4)
      1. Non-selective(1)
    13. GSK-3(8)
    14. Hexokinase(1)
    15. JAK(5)
    16. MAPK(15)
      1. p38 MAPK(8)
      2. MEK(5)
        MEK1(1)
      3. JNK(2)
    17. MAPKAP(1)
      1. MAPKAP2(1)
    18. mTOR(5)
    19. Myosin light chain kinase (MLCK)(1)
    20. Non-selective(2)
    21. PERK(1)
    22. PKA(5)
    23. PKC(32)
    24. PKG(2)
    25. PI-3K(6)
    26. Protein-serine/threonine kinase(3)
    27. Protein-tyrosine kinase(2)
      1. Non-selective(2)
    28. RIP kinase(3)
      1. RIP1(2)
    29. ROCK(7)
    30. RSK(1)
    31. Sphingosine kinase(1)
    32. Syk(1)
    33. Raf(2)
      1. B-Raf(2)
      2. c-RAF(2)
  13. Ligase(1)
    1. Ubiquitin/Ubl E2 conjugating(1)
      1. Ub-conjugating enzyme (E2) complex(1)
  14. Oxidase(4)
    1. Monoamine Oxidase(2)
      1. Non-selective(2)
    2. Tyrosinase(1)
  15. Oxygenase(8)
    1. COX(6)
      1. COX-2(2)
    2. 5-lipoxygenase(2)
  16. Phosphodiesterase(10)
    1. PDE1(4)
    2. PDE4(4)
    3. Non-selective(2)
    4. Sphingomyelinase(1)
      1. N-Smase(1)
  17. Phosphatase(25)
    1. Alkaline phosphatase(2)
    2. Protein-tyrosine phosphatase(7)
      1. PTP1B(1)
  18. Polymerase(9)
    1. DNA/RNA(5)
    2. Tankyrase (TNKS)(2)
    3. Telomerase(2)
  19. Protease / Peptidase(55)
    1. ACE2(1)
    2. Aminopeptidase(1)
    3. Angiotensin-Converting Enzyme (ACE)(1)
    4. Aspartic protease(1)
    5. Calpains(1)
    6. Caspase(11)
      1. Broad(2)
    7. Cathepsin(1)
      1. Cathepsin B(1)
    8. Deubiquitinating Enzymes(1)
      1. Ubiquitin C-terminal hydrolase(1)
    9. Dipeptidyl-peptidase 4(1)
    10. Elastase(1)
    11. Matrix metalloprotease(2)
      1. MMP-1(1)
    12. Methionine aminopeptidase-2(1)
    13. Other(4)
    14. Protease inhibitors and inhibitor cocktails(11)
    15. Prolyl endopeptidase (PREP)(1)
    16. Proteasome(12)
    17. Serine/cysteine protease(2)
    18. Secretase(4)
      1. γ(4)
  20. Reductase(3)
    1. Aldose reductase(1)
    2. NADH ubiquinone oxidoreductase(1)
  21. Synthase(14)
    1. HMG-CoA synthase(1)
  22. Transferase(36)
    1. ACAT(5)
    2. DGAT(2)
    3. DNA methyltransferase (DNMT)(4)
    4. Histone acetyltransferase (HAT)(1)
    5. Histone methyltransferase (HMTs)(6)
    6. Phosphorylase(1)
    7. Protein prenyltransferases(6)
    8. PORCN(4)
    9. Tankyrase (TNKS)(1)
4. Proteins - Other(59)
  1. Actin(8)
  2. Choline ester transfer protein (CETP)(1)
  3. GAPDH(1)
  4. GFAP(4)
  5. GFP(3)
  6. Histones(5)
    1. Bromodomain(4)
  7. HSP60(1)
  8. MAP2(2)
  9. mCherry(1)
  10. NeuN(3)
  11. Neurofilament L(1)
  12. Neurofilament M(1)
  13. N-WASP(1)
  14. Plasminogen PAI-1(1)
  15. STAT(5)
  16. Tubulin(4)
    1. βIII-tubulin(2)
    2. β-tubulin(1)
  17. Myelin basic protein(1)
  18. c-Fos(1)
  19. IBA1(1)
  20. Alpha-synuclein(1)
  21. VLP1(1)
Cell signaling
1. PI3K/Akt/mTOR(17)
  1. Akt(5)
  2. PI3K(6)
  3. mTOR(5)
2. TGF-Beta/SMAD/ROCK(16)
  1. Bcr-Abl(1)
  2. ROCK(7)
  3. TGF-Beta/ SMAD(8)
3. MAPK(19)
  1. p38 MAPK(9)
  2. MEK(5)
  3. ERK(2)
    1. ERK2 / MAPK1(1)
  4. JNK(2)
  5. Raf(1)
4. Estrogen & other Nuclear Receptors(19)
  1. Aryl Hydrocarbon Receptors(1)
  2. Estrogen Receptor signaling(16)
    1. Estrogen-α(2)
    2. Estrogen-β(2)
    3. Non-selective(12)
  3. Estrogen GPER receptors(1)
  4. PPAR(2)
5. Wnt/Beta-Catenin signaling(10)
  1. β-catenin(8)
6. Anticancer(15)
  1. Cytotoxic(7)
7. Anti-oxidant(10)
  1. Mitochondrial complex II(2)
8. Cyclic nucleotide and related(44)
  1. Adenylyl cyclase (AC)(2)
  2. cAMP(3)
  3. Guanyl cyclase (GC)(2)
  4. Inositol trisphosphate (IP3)(2)
  5. PKA(5)
  6. PKC(31)
9. Ca²⁺ signaling(29)
10. Gap channels (gap junctions)(3)
11. G protein(6)
  1. Small monomeric GTPase(2)
  2. G Protein (Heterotrimeric)(4)
12. Heatshock proteins(3)
  1. HSP90(3)
13. Hedgehog signaling(10)
14. Immune Checkpoint(3)
15. Lipid signaling(1)
16. Notch(4)
17. Transcription factors(9)
  1. HIF(1)
  2. NFAT(3)
  3. NGF(1)
  4. Stats(4)
Cell process
1. COVID-19 Research(191)
  1. Compound repurposing(36)
  2. Virus attachment / entry(10)
    1. TMPRSS2(1)
    2. ACE2(3)
    3. Endocytosis(6)
  3. Virus replication, transcription & maturation(16)
  4. Cytokine Storm / Immune response signaling(78)
    1. Angiotensin related(3)
    2. Cytokines, chemokines & NF-κB/I-κB(20)
      1. Chemokine Receptors(2)
      2. Cytokine Stimulation/ Production(10)
      3. NF-κB / IκB(8)
    3. Inflammasomes(6)
    4. JAK/STAT(9)
    5. MAPK Signaling(18)
      1. p38 MAPK(8)
      2. MEK(5)
      3. ERK(2)
        ERK2 / MAPK1(1)
      4. JNK(2)
      5. Raf(1)
    6. PI3K/Akt/mTOR(15)
      1. Akt(4)
      2. PI3K(6)
      3. mTOR(5)
    7. Protease-Activated Receptors(3)
    8. TLR (Toll-like receptors) signaling(6)
      1. TLR2(1)
      2. TLR7(3)
  5. Organoids(13)
  6. Cell culture reagents & buffers(44)
    1. Selection Antibiotics(8)
    2. Protease inhibitor cocktails and inhibitors(12)
  7. Cell stains, viability & proliferation(13)
  8. CRISPR/ Gene editing(13)
2. Apoptosis & cell cycle(48)
  1. Caspase(11)
  2. Inducers(13)
  3. p53(2)
  4. PARP(4)
    1. PARP-1(2)
    2. Non-selective(1)
  5. RIP kinase(1)
  6. Stains(13)
3. Cell Metabolism(75)
  1. Autophagy(11)
  2. Amyloid-β(12)
  3. Bioactive metabolites(3)
  4. DNA / RNA & protein synthesis(34)
    1. Genome editing / engineering(9)
  5. Oxidative Phosphorylation(5)
  6. Ubiquitin-proteasome system (UPS) (12)
4. Cytoskeleton and Extracellular Matrix(35)
  1. Actin(7)
  2. Matrix Metalloproteases (MMP)(3)
  3. Microtubule(5)
  4. ROCK (Rho-kinase)(7)
5. Immunology & Inflammation(176)
  1. Antivirals / Antibiotics / immunomodulators(143)
    1. Antibiotics(81)
    2. Antimicrobials(9)
    3. Antivirals(28)
      1. COVID-19/SARS-CoV-2 related(19)
    4. Immunosupressants / immunomodulators(10)
    5. Mycotoxin(4)
    6. T-cell Related(9)
  2. Cytokines, chemokines & NF-κB/I-κB(23)
    1. Chemokine Receptors(3)
    2. Cytokine Stimulation/ Production(10)
    3. JNK(2)
    4. NF-κB / IκB(8)
  3. Inflammasome(6)
  4. JAK/STAT(9)
  5. TLR (Toll-like receptors)(6)
    1. TLR2(1)
    2. TLR7(3)
    3. Non-selective(2)
6. Oxidative Stress(7)
  1. ROS(3)
  2. NOS(4)
7. Stem cells(112)
  1. Dedifferentiation(6)
  2. Differentiation(59)
    1. iPSCs & ESCs(18)
    2. Mesenchymal Stem cells (MSCs)(11)
    3. Neural Stem Cells (NSCs)(30)
      1. Neurotrophins(5)
  3. Organoids(14)
  4. Proliferation, self-renewal, maintenance(29)
  5. Reprogramming(22)
  6. Stem cell signaling(20)
8. Epigenetics(4)

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