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Biological Data
Biological description
AT1 (Angiotensin II receptor type 1) antagonist / blocker (Ki = 3.7 nM). It is also a PPARγ partial agonist.
Shows anti-hypertensive effects.
Recently investigated as part of COVID-19 compound repurposing.
Solubility & Handling
Solubility overview
Soluble in DMSO (20mM)
Important
This product is for RESEARCH USE ONLY and is not intended for therapeutic or diagnostic use. Not for human or veterinary use
Chemical Data
Chemical name
2-(4-{[4-Methyl-6-(1-methyl-1H-1,3-benzodiazol-2-yl)-2-propyl-1H-1,3-benzodiazol-1-yl]methyl}phenyl)benzoic acid
Chemical structure
Molecular Formula
C33 H30 N4 O2
SMILES
O=C(O)c1ccccc1c2ccc(cc2)Cn3c4cc(cc(c4nc3CCC)C)c5nc6ccccc6n5C
InChi
InChI=1S/C33H30N4O2/c1-4-9-30-35-31-21(2)18-24(32-34-27-12-7-8-13-28(27)36(32)3)19-29(31)37(30)20-22-14-16-23(17-15-22)25-10-5-6-11-26(25)33(38)39/h5-8,10-19H,4,9,20H2,1-3H3,(H,38,39)
InChiKey
RMMXLENWKUUMAY-UHFFFAOYSA-N
References for Telmisartan
References are publications that support the biological activity of the product
Telmisartan as tentative angiotensin receptor blocker therapeutic for COVID-19
Rothlin et al (2020)
Drug Dev Res. 1l10 : 1002
6-Substituted benzimidazoles as new nonpeptide angiotensin II receptor antagonists: synthesis, biological activity, and structure-activity relationships
Ries et al (1993)
J Med Chem 36(25) : 4040-51
Pharmacological characterization of the novel nonpeptide angiotensin II receptor antagonist, BIBR 277
Wienen et al (1993)
Br J Pharmacol. 110(1) : 245-52.
AT1 antagonist and PPARγ partial agonist
![Telmisartan [144701-48-4] Chemical Structure](https://m2stage-v2.hellobio.com/media/catalog/product//h/b/hb2558_1.png "Telmisartan [144701-48-4]")
Understanding purity and quality - a guide for life scientists 
