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Biological Data
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Biological description
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Selective, non-peptide AT1 antagonist which inhibits classical actions of angiotensin II.
Also down regulates TGF-β regulation. Shows anti-hypertensive action.
Recently studied as part of COVID-19 compound repurposing. |
Solubility & Handling
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Storage instructions
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RT (desiccate) |
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Solubility overview
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Soluble in water (100mM) and in DMSO (100mM) |
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Important
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This product is for RESEARCH USE ONLY and is not intended for therapeutic or diagnostic use. Not for human or veterinary use |
Chemical Data
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Chemical name
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2-Butyl-4-chloro-1-[[2'-(1H-tetrazol-5-yl)-[1,1'-biphenyl]-4-yl]methyl]-1H-imidazole-5-methanol potassium salt |
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Chemical structure
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![Losartan Potasssium [124750-99-8] Chemical Structure](data:image/png;base64,iVBORw0KGgoAAAANSUhEUgAAAAEAAAABCAQAAAC1HAwCAAAAC0lEQVR4nGP6zwAAAgcBApocMXEAAAAASUVORK5CYII= "Losartan Potasssium [124750-99-8]")
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Molecular Formula
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C22H22ClKN6O |
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PubChem identifier
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11476710 |
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SMILES
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CCCCC1=NC(Cl)=C(CO)N1CC2=CC=C(C3=CC=CC=C3C(N=N4)=NN4[K])C=C2 |
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InChi
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InChI=1S/C22H22ClN6O.K/c1-2-3-8-20-24-21(23)19(14-30)29(20)13-15-9-11-16(12-10-15)17-6-4-5-7-18(17)22-25-27-28-26-22;/h4-7,9-12,30H,2-3,8,13-14H2,1H3;/q-1;+1 |
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InChiKey
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OXCMYAYHXIHQOA-UHFFFAOYSA-N |
References for Losartan Potassium
References are publications that support the biological activity of the product
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Angiotensin receptor blockers as tentative SARS-CoV-2 therapeutics
Gurwitz (2020)
Drug Dev Res. : 1002/ddr.21656
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Long-term prehypertension treatment with losartan effectively prevents brain damage and stroke in stroke-prone spontaneously hypertensive rats
He et al (2019)
Int J Mol Med. 33(2) : 301-9
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The angiotensin receptor blocker, Losartan, inhibits mammary tumor development and progression to invasive carcinoma
Coulson et al (2017)
Oncotarget 8(12) : 18640-18656
Selective, non-peptide AT1 antagonist
![Losartan Potasssium [124750-99-8] Chemical Structure](https://m2stage-v2.hellobio.com/media/catalog/product//h/b/hb2977_1.png "Losartan Potasssium [124750-99-8]")
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