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Images
L-NAME product vial image | Hello Bio
L-NAME product vial image | Hello Bio
Biological Data
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Biological description
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Non-selective nitric oxide synthase (NOS) inhibitor. Also inhibits cyclic GMP (IC50 = 3.1 μM). Methyl ester pro-drug of L-NNA. Induces hypertension. |
Solubility & Handling
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Storage instructions
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Room temperature |
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Solubility overview
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Soluble in water (100mM) |
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Important
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This product is for RESEARCH USE ONLY and is not intended for therapeutic or diagnostic use. Not for human or veterinary use. |
Chemical Data
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Chemical name
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Nomega-Nitro-L-arginine methyl ester hydrochloride |
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Chemical structure
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![L-NAME [51298-62-5] Chemical Structure](data:image/png;base64,iVBORw0KGgoAAAANSUhEUgAAAAEAAAABCAQAAAC1HAwCAAAAC0lEQVR4nGP6zwAAAgcBApocMXEAAAAASUVORK5CYII= "L-NAME [51298-62-5]")
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Molecular Formula
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C7H15N5O4.HCl |
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PubChem identifier
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135193 |
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SMILES
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COC(=O)[C@H](CCCN=C(N)N[N+](=O)[O-])N.Cl |
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InChi
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InChI=1S/C7H15N5O4.ClH/c1-16-6(13)5(8)3-2-4-10-7(9)11-12(14)15;/h5H,2-4,8H2,1H3,(H3,9,10,11);1H/t5-;/m0./s1 |
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InChiKey
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QBNXAGZYLSRPJK-JEDNCBNOSA-N |
References for L-NAME
References are publications that support the biological activity of the product
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L-NAME in the cardiovascular system - nitric oxide synthase activator?
Kopincová J et al (2012)
Pharmacol Rep 64(3) : 511-20.
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Nitric oxide synthases: structure, function and inhibition.
Alderton WK et al (2001)
Biochem J 357(Pt 3) : 593-615.
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Characterization of three inhibitors of endothelial nitric oxide synthase in vitro and in vivo.
Rees DD et al (1990)
Br J Pharmacol 101(3) : 746-52.
Publications
These publications cite the use of L-NAME purchased from Hello Bio:
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Vascular remodelling in a mouse model of heart failure with preserved ejection fraction.
Sanhueza-Olivares F et al (2025)
The Journal of physiology
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Cerebellar interneurons control fear memory consolidation via learning-induced HCN plasticity.
Carzoli KL et al (2023)
Cell reports 42 : 113057
Non-selective NOS inhibitor. Induces hypertension.
![L-NAME [51298-62-5] Chemical Structure](https://m2stage-v2.hellobio.com/media/catalog/product//h/b/hb1352.png "L-NAME [51298-62-5]")
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