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Biological Data
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Biological description
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Potent, selective guanylyl cyclase inhibitor (IC50 = ~20 nM). Shows anxiolytic and anti-tumour actions. Also shows potential memory disturbing effects. |
Solubility & Handling
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Storage instructions
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+4°C |
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Solubility overview
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Soluble in DMSO (100mM) and in ethanol (20 mM, gentle warming) |
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Important
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This product is for RESEARCH USE ONLY and is not intended for therapeutic or diagnostic use. Not for human or veterinary use. |
Chemical Data
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Chemical name
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1H-[1,2,4]Oxadiazolo[4,3-a]quinoxalin-1-one |
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Chemical structure
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![ODQ [41443-28-1] Chemical Structure](data:image/png;base64,iVBORw0KGgoAAAANSUhEUgAAAAEAAAABCAQAAAC1HAwCAAAAC0lEQVR4nGP6zwAAAgcBApocMXEAAAAASUVORK5CYII= "ODQ [41443-28-1]")
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Molecular Formula
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C9H5N3O2 |
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SMILES
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C1=CC=C2C(=C1)N=CC3=NOC(=O)N23 |
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InChi
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InChI=1S/C9H5N3O2/c13-9-12-7-4-2-1-3-6(7)10-5-8(12)11-14-9/h1-5H |
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InChiKey
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LZMHWZHOZLVYDL-UHFFFAOYSA-N |
References for ODQ
References are publications that support the biological activity of the product
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In vivo microdialysis study of a specific inhibitor of soluble guanylyl cyclase on the glutamate receptor/nitric oxide/cyclic GMP pathway.
Fedele et al (1996)
Br J Pharmacol 119(3) : 590-4
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Nitric oxide-dependent long-term potentiation is blocked by a specific inhibitor of soluble guanylyl cyclase.
Boulton et al (1995)
Neuroscienec 69(3) : 699-703
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Potent and selective inhibition of nitric oxide-sensitive guanylyl cyclase by 1H-[1,2,4]oxadiazolo[4,3-a]quinoxalin-1-one.
Garthwaite et al (1995)
Moll Pharmacol 48(2) : 184-8
Potent, selective guanylyl cyclase inhibitor
![ODQ [41443-28-1] Chemical Structure](https://m2stage-v2.hellobio.com/media/catalog/product//h/b/hb2900.png "ODQ [41443-28-1]")
Understanding purity and quality - a guide for life scientists 
