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β-Amyloid Peptide (1-42) (human)

(HB9805)
Publications (3)

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Product overview

Name β-Amyloid Peptide (1-42) (human)
Biological description

The β-amyloid (Aβ) 1-42 peptide has been proposed to affect neuronal degeneration and has been implicated in the pathology of Alzheimer’s disease.
Purity >95%
Description β-Amyloid (1-42) protein fragment. Implicated in Alzheimer's disease.
Biological Data Solubility & Handling Chemical Data Related Areas Calculators Technical guides (2) Reviews (5) Publications (3) References (2)
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β-Amyloid Peptide (1-42) (human) (HB9805) testing

β-Amyloid Peptide (1-42) (human) (HB9805) testing

Acute hippocampal slice (n = 4 Wistar rats, post-natal day 25-30). 3hrs exposure to 2µM amyloid-beta. Field excitatory post-synaptic potential (fEPSP) recordings. Stimulating CA3/Schaffer Collaterals; recording from CA1 field. (left) Evoked fibre volley (FV) amplitude as a function of stimulation magnitude. (right) Evoked fEPSP slope as a function of stimulation magnitude. Analysis by simple linear regression.
β-Amyloid Peptide (1-42) (human) (HB9805) testing

β-Amyloid Peptide (1-42) (human) (HB9805) testing

Acute hippocampal slice (n = 4 Wistar rats, post-natal day 25-30). 3hrs exposure to 2µM amyloid-beta. Field excitatory post-synaptic potential (fEPSP) recordings. Stimulating CA3/Schaffer Collaterals; recording from CA1 field. (left) Evoked fibre volley (FV) amplitude as a function of stimulation magnitude. (right) Evoked fEPSP slope as a function of stimulation magnitude. Analysis by simple linear regression.

Biological Data

Application notes

Please see our Amyloid Beta Protocol

Solubility & Handling

Storage instructions -20°C
Solubility overview

Soluble in 1.0% NH4OH
Handling

Please note that this product is supplied as a lyophilized solid and may be very hard to visualize.

Amyloid beta peptides are prone to aggregation and as such, there are a variety of published methods for handling amyloid beta peptides.

We recommend using NH4OH with this product - you should use 1.0% NH4OH as the solvent followed by buffer (for example 1X PBS).

  1. Add 1.0% NH4OH directly to the lyophilized peptide (~70-80 μl for 1mg of peptide). Do not store the peptide in 1.0% NH4OH.
  2. Immediately dilute your solution to a concentration of ~1mg/mL or less your buffer (e.g 1X PBS, water or an alternative buffer).
  3. Vortex gently to mix (less than 1 minute).

Note: This method may not completely remove pre-aggregates. Vortexing may encourage seeding and further aggregation of the peptide.
Important This product is for RESEARCH USE ONLY and is not intended for therapeutic or diagnostic use. Not for human or veterinary use

Calculators

Molarity

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x
x
More Info

Dilution

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x
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Chemical Data

Purity >95%
UniProt ID P05067
Chemical name DAEFRHDSGYEVHHQKLVFFAEDVGSNKGAIIGLMVGGVVIA
Molecular Weight 4514.08
Chemical structure Amyloid beta (1-42) (human) TFA | [107761-42-2] Chemical Structure
Molecular Formula C203H311N55O60S
Sequence (one letter) DAEFRHDSGYEVHHQKLVFFAEDVGSNKGAIIGLMVGGVVIA
CAS Number 107761-42-2
PubChem identifier 71773143
SMILES CC[C@H](C)[C@@H](C(=O)N[C@@H]([C@@H](C)CC)C(=O)NCC(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCSC)C(=O)N[C@@H](C(C)C)C(=O)NCC(=O)NCC(=O)N[C@@H](C(C)C)C(=O)N[C@@H](C(C)C)C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H](C)C(=O)O)NC(=O)[C@H](C)NC(=O)CNC(=O)[C@H](CCCCN)NC(=O)[C@H](CC(=O)N)NC(=O)[C@H](CO)NC(=O)CNC(=O)[C@H](C(C)C)NC(=O)[C@H](CC(=O)O)NC(=O)[C@H](CCC(=O)O)NC(=O)[C@H](C)NC(=O)[C@H](CC1=CC=CC=C1)NC(=O)[C@H](CC2=CC=CC=C2)NC(=O)[C@H](C(C)C)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CCCCN)NC(=O)[C@H](CCC(=O)N)NC(=O)[C@H](CC3C=NC=N3)NC(=O)[C@H](CC4C=NC=N4)NC(=O)[C@H](C(C)C)NC(=O)[C@H](CCC(=O)O)NC(=O)[C@H](CC5=CC=C(C=C5)O)NC(=O)CNC(=O)[C@H](CO)NC(=O)[C@H](CC(=O)O)NC(=O)[C@H](CC6C=NC=N6)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@H](CC7=CC=CC=C7)NC(=O)[C@H](CCC(=O)O)NC(=O)[C@H](C)NC(=O)[C@H](CC(=O)O)N
Structure image Amyloid beta (1-42) (human) TFA | [107761-42-2] Chemical Structure
InChiKey XPESWQNHKICWDY-QYFPAAMGSA-N
MDL number MFCD00163049
Appearance Lyophilized White solid
Protein length 42

References for β-Amyloid Peptide (1-42) (human)

References are publications that support the biological activity of the product

  • Amyloid-peptide β 42 Enhances the Oligomerization and Neurotoxicity of apoE4: The C-terminal Residues Leu279, Lys282 and Gln284 Modulate the Structural and Functional Properties of apoE4

    Dafnis I et al (2018) Neuroscience 394 : 144-155
    Read more (PubMedID: 30367942)

  • β-Amyloid: the key peptide in the pathogenesis of Alzheimer's disease

    Sun X et al (2015) Front Pharmacol 6 : 221
    Read more (PubMedID: 26483691)

2 Item(s)

Publications
Submit Yours Now
These publications cite the use of β-Amyloid Peptide (1-42) (human) purchased from Hello Bio:

  • The Alzheimer risk factor CD2AP causes dysfunction of the brain vascular network

    Vandal et al (2022) bioRxiv
    PubMedID: https://www.biorxiv.org/content/

  • Study of the potential neuroprotective effect of Dunaliella salina extract in SH-SY5Y cell model

    Gallego et al (2021) Anal Bioanal Chem . : doi: 10.1007/s00216-021-03819-1.
    PubMedID: 34923590

  • In vitro Neuroprotective Potential and Lipidomics Study of Olive Leaves Extracts Enriched in Triterpenoids

    Gallego R et al (2021) Front Nutr 8 : 769218
    PubMedID: 34708068

3 Item(s)

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Grouped product items
Order: HB9805
Pack Price Qty
100μg
$100
500μg
$166
1mg
$308
β-Amyloid (1-42) protein fragment. Implicated in Alzheimer's disease.
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