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Images
ZD 7288 product vial image | Hello Bio
ZD 7288 product vial image | Hello Bio
Biological Data
Biological description
Hyperpolarization-activated, cyclic nucleotide-gated cation (HCN) channel blocker (IC50 = 15.0 µM).
Modulates sino-atrial node function; blocks the hyperpolarization-activated inward current If and inhibits Ih in central neurons.
Also inhibits Na+ currents in dorsal root ganglion neurons (IC50 = 1.17 µM).
Blocks long term potentiation (LTP) induction and displays anxiolytic properties.
Also increases doubling time of embryonic stem cells (ESCs) and modulates differentiation outcomes. Active in vivo .
Solubility & Handling
Storage instructions
+4°C (desiccate)
Solubility overview
Soluble in water (100mM) or DMSO (100mM)
Important
This product is for RESEARCH USE ONLY and is not intended for therapeutic or diagnostic use. Not for human or veterinary use.
Chemical Data
Chemical name
4-Ethylphenylamino-1,2-dimethyl-6-methylaminopyrimidinium chloride
Chemical structure
Molecular Formula
C15 H21 ClN4
PubChem identifier
123983
SMILES
CCN(C1=CC=CC=C1)C2=CC(=NC)N(C(=N2)C)C.Cl
InChi
InChI=1S/C15H20N4.ClH/c1-5-19(13-9-7-6-8-10-13)15-11-14(16-3)18(4)12(2)17-15;/h6-11H,5H2,1-4H3;1H
InChiKey
DUWKUHWHTPRMAP-UHFFFAOYSA-N
References for ZD 7288
References are publications that support the biological activity of the product
ZD7288, a blocker of the HCN channel family, increases doubling time of mouse embryonic stem cells and modulates differentiation outcomes in a context-dependent manner.
Omelyanenko et al (2016)
Springerplus 16 : 5:41
Intrahippocampal infusion of the Ih blocker ZD7288 slows evoked theta rhythm and produces anxiolytic-like effects in the elevated plus maze.
Yeung M et al (2013)
Hippocampus 23(4) : 278-86.
Is ZD7288 a selective blocker of hyperpolarization-activated cyclic nucleotide-gated channel currents?
Wu X et al (2012)
Channels (Austin) 6(6) : 438-42.
Inhibitory actions of ZENECA ZD7288 on whole-cell hyperpolarization activated inward current (If) in guinea-pig dissociated sinoatrial node cells.
BoSmith RE et al (1993)
Br J Pharmacol 110(1) : 343-9.
Publications
These publications cite the use of ZD 7288 purchased from Hello Bio:
Morpho-electric diversity of human hippocampal CA1 pyramidal neurons.
Mertens EJ et al (2024)
Cell reports 43 : 114100
Presynaptic cGMP sets synaptic strength in the striatum and is important for motor learning
Fieblinger T et al (2022)
EMBO Rep 23(8) : e54361
Non-uniform distribution of dendritic nonlinearities differentially engages thalamostriatal and corticostriatal inputs onto cholinergic interneurons
Goldberg et al (2021)
bioRxiv https://doi.org/10.1101/2021.11.29.470423 : doi
Resilience to anhedonia-passive coping induced by early life experience is linked to a long-lasting reduction of Ih current in VTA dopaminergic neurons
D'Addario SL et al (2021)
Neurobiol Stress 14 : 100324
GIRK1-Mediated Inwardly Rectifying Potassium Current Is a Candidate Mechanism Behind Purkinje Cell Excitability, Plasticity, and Neuromodulation
Lippiello P et al (2020)
Cerebellum 19(6) : 751-761
HCN channel blocker. Modulates sino-atrial node function.
![ZD 7288 [133059-99-1] Chemical Structure](https://m2stage-v2.hellobio.com/media/catalog/product//h/b/hb1152.png "ZD 7288 [133059-99-1]")
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