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Biological Data
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Biological description
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Akt (PKB) inhibitor. Binds at an allosteric site. Interferes with PH domain-PIP3 binding and enhances Akt ubiquitination. Blocks mTORC1/2, decreases glucose uptake and cell viability. Shows anti-tumor actions. |
Solubility & Handling
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Storage instructions
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-20°C |
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Solubility overview
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Soluble in DMSO (75mM) or ethanol (75mM) |
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Important
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This product is for RESEARCH USE ONLY and is not intended for therapeutic or diagnostic use. Not for human or veterinary use. |
Chemical Data
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Chemical name
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(2E,6E)-2,6-Bis(4-pyridinylmethylene)cyclohexanone |
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Chemical structure
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![SC 66 [871361-88-5] Chemical Structure](data:image/png;base64,iVBORw0KGgoAAAANSUhEUgAAAAEAAAABCAQAAAC1HAwCAAAAC0lEQVR4nGP6zwAAAgcBApocMXEAAAAASUVORK5CYII= "SC 66 [871361-88-5]")
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Molecular Formula
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C18H16N2O |
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PubChem identifier
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6018993 |
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SMILES
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O=C(/C(CCC3)=C/C2=CC=NC=C2)/C3=C/C1=CC=NC=C1 |
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InChiKey
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CYVVJSKZRBZHAV-UNZYHPAISA-N |
References for SC 66
References are publications that support the biological activity of the product
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AKT inhibitors promote cell death in cervical cancer through disruption of mTOR signaling and glucose uptake.
Rashmi R et al (2014)
PLoS One 9(4) : e92948.
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Deactivation of Akt by a small molecule inhibitor targeting pleckstrin homology domain and facilitating Akt ubiquitination.
Jo H et al (2011)
Proc Natl Acad Sci U S A 108(16) : 6486-91.
![SC 66 [871361-88-5] Chemical Structure](https://m2stage-v2.hellobio.com/media/catalog/product//h/b/hb1252.png "SC 66 [871361-88-5]")
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