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Biological Data
Biological description
Salvinorin B (SALB) is a pharmacologically inert ligand that potently and selectively activates the KORD (the κ-opioid designer receptor (DREADD)) (EC50 = 11.8 nM).
CNO dihydrochloride (water soluble), Clozapine N-oxide (CNO) freebase, Compound 21 and perlapine freebase also available.
Please note this item is not for sale in Canada
Solubility & Handling
Storage instructions
-20°C
Solubility overview
Soluble in DMSO (20 mM)
Handling
This compound is light sensitive; we therefore recommend protecting the solid and solutions from exposure to light.
Salvinorin B (SalB) is unstable in solution and we recommend that solutions are stored at -20°C and used within 24 hours.
Important
This product is for RESEARCH USE ONLY and is not intended for therapeutic or diagnostic use. Not for human or veterinary use.
Chemical Data
Chemical name
(2S,4aR,6aR,7R,9S,10aS,10bR)-2-(3-Furanyl)dodecahydro-9-hydroxy-6a,10b-dimethyl-4,10-dioxo-2H-naphtho[2,1-c]pyran-7-carboxylic acid methyl ester
Chemical structure
Molecular Formula
C21 H26 O7
PubChem identifier
11440685
SMILES
C[C@@]12CC[C@H]3C(=O)O[C@@H](C[C@@]3([C@H]1C(=O)[C@H](C[C@H]2C(=O)OC)O)C)C4=COC=C4
Source
Extracted from salvia divinorum
InChi
InChI=1S/C21H26O7/c1-20-6-4-12-19(25)28-15(11-5-7-27-10-11)9-21(12,2)17(20)16(23)14(22)8-13(20)18(24)26-3/h5,7,10,12-15,17,22H,4,6,8-9H2,1-3H3/t12-,13-,14-,15-,17-,20-,21-/m0/s1
InChiKey
BLTMVAIOAAGYAR-CEFSSPBYSA-N
Appearance
Off-white solid
References for Salvinorin B (SALB)
References are publications that support the biological activity of the product
DREADDS: Use and application in behavioral neuroscience.
Smith et al (206)
Behav Neurosci 130(2) : 137-55.
DREADDs: The Power of the Lock, the Weakness of the Key. Favoring the Pursuit of Specific Conditions Rather than Specific Ligands.
Goutaudier et al (2019)
eNeuro 6 : (5)
Behavioral and Physiological Effects of a Novel Kappa-Opioid Receptor-Based DREADD in Rats.
Marchant et al (2016)
Neuropsychopharmacology 41(2) : 402-9.
A New DREADD Facilitates the Multiplexed Chemogenetic Interrogation of Behavior.
Vardy et al (2015)
Neuron. 86(4) : 936-46.
Antinociceptive and hypothermic effects of Salvinorin A are abolished in a novel strain of kappa-opioid receptor-1 knockout mice.
Ansonoff MA et al (2006)
J Pharmacol Exp Ther 318 (2): : 641-8.
Publications
These publications cite the use of Salvinorin B (SALB) purchased from Hello Bio:
The parasubthalamic nucleus refeeding ensemble delays feeding initiation and hastens water drinking.
Dunning JL et al (2024)
Molecular psychiatry
The parasubthalamic nucleus refeeding ensemble delays feeding initiation
Dunning et al (2023)
bioRxiv : https://doi.org/10.1101/2023.01.28.525750
Hypothalamic astrocyte control systemic glucose metabolism and energy balance via regulation of extra-synaptic glutamate signaling
Luquet et al (2022)
Biorxiv : https://doi.org/10.1101/2022.02.16.480737
Inhibitory Fear Memory Engram in the Mouse Central Lateral Amygdala
Hou et al et al (2022)
Cell Reports 72
Microglia modulate stable wakefulness via the thalamic reticular nucleus in mice
Liu et al (2021)
Nat Commun. : 12(1)
Potent, selective KORD DREADD activator
![Salvinorin B | [92545-30-7] Chemical Structure](https://m2stage-v2.hellobio.com/media/catalog/product//h/b/hb4887.png "Salvinorin B | [92545-30-7]")
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