Lac-Phe
(HB8782)
Certificate of Analysis
Product overview
| Name | Lac-Phe |
| Alternative names | N-l-lactoyl-Phe |
| Purity | >99% |
| Description |
Exercise induced metabolite that suppresses food intake and obesity |
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Images
Lac-Phe (N-lactoyl-phenylalanine) product vial image | Hello Bio
Lac-Phe (N-lactoyl-phenylalanine) product vial image | Hello Bio
Biological Data
| Biological description |
L-lactate-derived metabolite which is upregulated following exercise. Recently shown to reduce food intake by ~50% in diet-induced obese (DIO) mice, without affecting movement or energy expenditure. Decreases body weight, adiposity and improves glucose homeostasis when chronically administered. |
Solubility & Handling
| Storage instructions | Room temperature |
| Solubility overview | Soluble in water (50 mM), and in DMSO (100 mM) |
| Important | This product is for RESEARCH USE ONLY and is not intended for therapeutic or diagnostic use. Not for human or veterinary use |
Chemical Data
| Purity | >99% |
| Chemical name | (2S)-2-[(2S)-2-hydroxypropanamido]-3-phenylpropanoic acid |
| Molecular Weight | 237.3 |
| Chemical structure |
![Lac-Phe [183241-73-8] Chemical Structure](https://m2stage-v2.hellobio.com/media/catalog/product//h/b/hb8782.png "Lac-Phe [183241-73-8]")
|
| Molecular Formula | C12H15NO4 |
| CAS Number | 183241-73-8 |
| PubChem identifier | 69759947 |
| SMILES | C[C@H](O)C(=O)N[C@@H](Cc1ccccc1)C(=O)O |
| Source | Synthetic |
| InChi | InChI=1S/C12H15NO4/c1-8(14)11(15)13-10(12(16)17)7-9-5-3-2-4-6-9/h2-6,8,10,14H,7H2,1H3,(H,13,15)(H,16,17)/t8-,10-/m0/s1 |
| Appearance | White solid |
Technical guides
Understanding purity and quality - a guide for life scientists References for Lac-Phe
References are publications that support the biological activity of the product
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An exercise-inducible metabolite that suppresses feeding and obesity.
Li VL et al (2022) Nature 606 : 785-790 -
N-lactoyl-amino acids are ubiquitous metabolites that originate from CNDP2-mediated reverse proteolysis of lactate and amino acids.
Jansen RS et al (2015) Proceedings of the National Academy of Sciences of the United States of America 112 : 6601-6
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