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Images
CGP 52432 product vial image | Hello Bio
CGP 52432 product vial image | Hello Bio
Biological Data
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Biological description
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Potent and selective GABAB receptor antagonist (IC50 = 85 nM). |
Solubility & Handling
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Storage instructions
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+4°C (desiccate) |
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Solubility overview
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Soluble in water (10mM, gentle warming) |
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Important
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This product is for RESEARCH USE ONLY and is not intended for therapeutic or diagnostic use. Not for human or veterinary use. |
Chemical Data
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Chemical name
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3-[[(3,4-Dichlorophenyl)methyl]amino]propyl]diethoxymethyl)phosphinic acid |
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Chemical structure
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![CGP 52432 [139667-74-6] Chemical Structure](data:image/png;base64,iVBORw0KGgoAAAANSUhEUgAAAAEAAAABCAQAAAC1HAwCAAAAC0lEQVR4nGP6zwAAAgcBApocMXEAAAAASUVORK5CYII= "CGP 52432 [139667-74-6]")
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Molecular Formula
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C15H24Cl2NO4P |
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PubChem identifier
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132252 |
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SMILES
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ClC1=CC=C(CNCCCP(C(OCC)OCC)(O)=O)C=C1Cl |
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InChiKey
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GJZVQXWEIYRHBE-UHFFFAOYSA-N |
References for CGP 52432
References are publications that support the biological activity of the product
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Blockade of the GABA(B) receptor increases neurogenesis in the ventral but not dorsal adult hippocampus: relevance to antidepressant action.
Felice D et al (2012)
Neuropharmacology 63(8) : 1380-8.
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GABA(B) receptors as potential targets for drugs able to prevent excessive excitatory amino acid transmission in the spinal cord.
Bonanno G et al (1998)
Eur J Pharmacol 362(2-3) : 143-8.
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CGP 52432: a novel potent and selective GABAB autoreceptor antagonist in rat cerebral cortex.
Lanza M et al (1993)
Eur J Pharmacol 237(2-3) : 191-5.
Publications
These publications cite the use of CGP 52432 purchased from Hello Bio:
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Cholinergic activation of corticofugal circuits in the adult mouse prefrontal cortex.
Gulledge AT (2023)
bioRxiv : the preprint server for biology
Potent, selective GABAB receptor antagonist
![CGP 52432 [139667-74-6] Chemical Structure](https://m2stage-v2.hellobio.com/media/catalog/product//h/b/hb0958.png "CGP 52432 [139667-74-6]")
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