The store will not work correctly when cookies are disabled.
Biological Data
|
Biological description
|
Potent IP3 receptor inhibitor. Inhibits P3-mediated Ca2+ release (IC50 = 358 nM). Selective for IP3 receptors over ryanodine receptors. Inhibits sarcoplasmic/endoplasmic reticulum Ca2+ ATPase SERCA pump. |
Solubility & Handling
|
Storage instructions
|
-20°C (desiccate) |
|
Solubility overview
|
Soluble in DMSO (2mM) or ethanol (2mM) |
|
Important
|
This product is for RESEARCH USE ONLY and is not intended for therapeutic or diagnostic use. Not for human or veterinary use. |
Chemical Data
|
Chemical name
|
(1R,4aR,11R,12aS,13S,16aS,23R,24aS)-Eicosahydro-5H,17H-1,23:11,13-diethano-2H,14H-[1,11]dioxacycloeicosino[2,3-b:12,13-b']dipyridine |
|
Chemical structure
|
![(-)-Xestospongin C [88903-69-9] Chemical Structure](data:image/png;base64,iVBORw0KGgoAAAANSUhEUgAAAAEAAAABCAQAAAC1HAwCAAAAC0lEQVR4nGP6zwAAAgcBApocMXEAAAAASUVORK5CYII= "(-)-Xestospongin C [88903-69-9]")
|
|
Molecular Formula
|
C28H50N2O2 |
|
PubChem identifier
|
9846431 |
|
SMILES
|
[H][C@]12[C@@H](CCCCCC[C@@H]3CCN(CCC[C@H]4CCCCCC5)[C@@]4([H])O3)CCCN1CC[C@@H]5O2 |
|
InChiKey
|
PQYOPBRFUUEHRC-HCKQMYSWSA-N |
References for (-)-Xestospongin C
References are publications that support the biological activity of the product
-
Xestospongin C is a potent inhibitor of SERCA at a vertebrate synapse.
Castonguay A et al (2002)
Cell Calcium 32(1) : 39-47.
-
Xestospongin C is an equally potent inhibitor of the inositol 1,4,5-trisphosphate receptor and the endoplasmic-reticulum Ca(2+) pumps.
De Smet P et al (1999)
Cell Calcium 26(1-2) : 9-13.
-
Xestospongins: potent membrane permeable blockers of the inositol 1,4,5-trisphosphate receptor.
Gafni J et al (1997)
Neuron 19(3) : 723-33.
Potent IP3 receptor inhibitor
![(-)-Xestospongin C [88903-69-9] Chemical Structure](https://m2stage-v2.hellobio.com/media/catalog/product//h/b/hb1241.png "(-)-Xestospongin C [88903-69-9]")
Understanding purity and quality - a guide for life scientists