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Biological Data
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Biological description
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Cell permeable, selective and irreversible IKKalpha and beta kinase activity inhibitor. NF-kappaB inhibitor. Blocks phosphorylation and degradation of IkappaBalpha. Antihepatotoxic. 5-Lipoxygenase (5-LOX) inhibitor. Anti-inflammatory. HIV-1 integrase inhibitor. Anticancer and antiproliferative compound. Modulates androgen receptor (AR) activation. Apoptosis inducer via downregulation of PKCepsilon. DNA topoisomerase IIalpha inhibitor. G protein-coupled receptor-35 (GPR35) agonist. Inhibits adipogenic differentiation of mesenchymal stem cells (hAMSCs) through ERK pathway. STAT1 protein dephosphorylation inhibitor. Antifibrotic. |
Solubility & Handling
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Storage instructions
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+4°C |
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Important
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This product is for RESEARCH USE ONLY and is not intended for therapeutic or diagnostic use. Not for human or veterinary use. |
Chemical Data
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Chemical name
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7-Methoxy-5,11,12-trihydroxy-coumestan |
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Chemical structure
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![Wedelolactone [524-12-9] Chemical Structure](data:image/png;base64,iVBORw0KGgoAAAANSUhEUgAAAAEAAAABCAQAAAC1HAwCAAAAC0lEQVR4nGP6zwAAAgcBApocMXEAAAAASUVORK5CYII= "Wedelolactone [524-12-9]")
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SMILES
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COc1cc(O)c2c(OC(=O)c3c2oc4cc(O)c(O)cc34)c1 |
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InChiKey
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XQDCKJKKMFWXGB-UHFFFAOYSA-N |
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Appearance
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Yellow to amber crystalline powder |
Selective IKKα and IKKβ kinase activity inhibitor. NF-κB inhibitor.
![Wedelolactone [524-12-9] Chemical Structure](https://m2stage-v2.hellobio.com/media/catalog/product//h/b/hb4124.png "Wedelolactone [524-12-9]")
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