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Biological Data
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Biological description
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Tubocurarine is a competitive, non-selective nicotinic acetylcholine receptors (nACHR)
antagonist which blocks neuromuscular transmission.
Tubocurarine is also a GABAA and 5-HT3 receptor antagonist. |
Solubility & Handling
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Storage instructions
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+4°C (desiccate) |
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Solubility overview
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Soluble in water (25 mM), and in DMSO (10 mM) |
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Important
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This product is for RESEARCH USE ONLY and is not intended for therapeutic or diagnostic use. Not for human or veterinary use |
Chemical Data
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Chemical name
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(13aR,25aS)-2,3,13a,14,15,16,25,25a-Octahydro-9,19-dihydroxy-18,29-dimethoxy-1,14,14-trimethyl-13H-4,6:21,24-dietheno-8,12-metheno-1H-pyrido[3',2':14,15][1,11]dioxacycloeicosino[2,3,4-ij]isoquinolinium chloride hydrochloride pentahydrate |
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Chemical structure
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![(+)-Tubocurarine [6989-98-6] Chemical Structure](data:image/png;base64,iVBORw0KGgoAAAANSUhEUgAAAAEAAAABCAQAAAC1HAwCAAAAC0lEQVR4nGP6zwAAAgcBApocMXEAAAAASUVORK5CYII= "(+)-Tubocurarine [6989-98-6]")
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Molecular Formula
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C37H41ClN2O6.HCl.5H2O |
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SMILES
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CN1CCC2=CC(=C3C=C2[C@@H]1CC4=CC=C(C=C4)OC5=C6[C@@H](CC7=CC(=C(C=C7)O)O3)[N+](CCC6=CC(=C5O)OC)(C)C)OC.O.O.O.O.O.Cl.[Cl-] |
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InChi
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InChI=1S/C37H40N2O6.2ClH.5H2O/c1-38-14-12-24-19-32(42-4)33-21-27(24)28(38)16-22-6-9-26(10-7-22)44-37-35-25(20-34(43-5)36(37)41)13-15-39(2,3)29(35)17-23-8-11-30(40)31(18-23)45-33;;;;;;;/h6-11,18-21,28-29H,12-17H2,1-5H3,(H-,40,41);2*1H;5*1H2/t28-,29+;;;;;;; |
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InChiKey
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WMIZITXEJNQAQK-GGDSLZADSA-N |
References for (+)-Tubocurarine chloride
References are publications that support the biological activity of the product
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Pre-and post-junctional effects of tubocurarine and other nicotinic antagonists during repetitive stimulation in the rat.
Gibb and Marhsall (1984)
J Physiol 351 : 275-97
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The effect of (+)-tubocurarine on neuromuscular transmission during repetitive stimulation in the rat, mouse, and frog.
Magleby et al (1981)
J Physiol. 312 : 97-113
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The actions of tubocurarine at the frog neuromuscular junction.
Colquhoun et al (1979)
J Physiol. 293 : 247-84
Nicotinic acetylcholine receptors (nACHR) antagonist. Neuromuscular blocker.
![(+)-Tubocurarine [6989-98-6] Chemical Structure](https://m2stage-v2.hellobio.com/media/catalog/product//h/b/hb2050_1.png "(+)-Tubocurarine [6989-98-6]")
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