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Biological Data
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Biological description
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Selective STAT3 inhibitor. Inhibits STAT3 activation, dimerization and nuclear translocation. Enhances ROS formation. Shows apoptotic and anti-cancer actions. |
Solubility & Handling
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Storage instructions
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+4°C |
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Solubility overview
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Soluble in DMSO (50mM) |
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Important
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This product is for RESEARCH USE ONLY and is not intended for therapeutic or diagnostic use. Not for human or veterinary use. |
Chemical Data
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Chemical name
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6-Nitrobenzo[b]thiophene 1,1-dioxide |
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Chemical structure
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![Stattic [19983-44-9] Chemical Structure](data:image/png;base64,iVBORw0KGgoAAAANSUhEUgAAAAEAAAABCAQAAAC1HAwCAAAAC0lEQVR4nGP6zwAAAgcBApocMXEAAAAASUVORK5CYII= "Stattic [19983-44-9]")
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Molecular Formula
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C8H5NO4S |
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PubChem identifier
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2779853 |
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SMILES
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C1=CC(=CC2=C1C=CS2(=O)=O)[N+](=O)[O-] |
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InChi
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InChI=1S/C8H5NO4S/c10-9(11)7-2-1-6-3-4-14(12,13)8(6)5-7/h1-5H |
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InChiKey
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ZRRGOUHITGRLBA-UHFFFAOYSA-N |
References for Stattic
References are publications that support the biological activity of the product
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Stat3 inhibitor Stattic exhibits potent antitumor activity and induces chemo- and radio-sensitivity in nasopharyngeal carcinoma.
Pan Y et al (2013)
PLoS One 8(1) : e54565.
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The STAT3 inhibitor stattic impairs cardiomyocyte mitochondrial function through increased reactive oxygen species formation.
Boengler K et al (2013)
Curr Pharm Des 19(39) : 6890-5.
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Stattic: a small-molecule inhibitor of STAT3 activation and dimerization.
Schust J et al (2006)
Chem Biol 13(11) : 1235-42.
Selective STAT3 inhibitor
![Stattic [19983-44-9] Chemical Structure](https://m2stage-v2.hellobio.com/media/catalog/product//h/b/hb1437.png "Stattic [19983-44-9]")
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