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Biological Data
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Biological description
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Potent GABAB receptor agonist. Evokes hyperpolarizations in septal neurones (EC50 = 50 nM). Shows antidepressant actions. Blood-brain barrier permeable. |
Solubility & Handling
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Storage instructions
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Room temperature (desiccate) |
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Solubility overview
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Soluble in water (100mM) |
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Important
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This product is for RESEARCH USE ONLY and is not intended for therapeutic or diagnostic use. Not for human or veterinary use. |
Chemical Data
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Chemical name
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3-Aminopropyl(methyl)phosphinic acid |
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Chemical structure
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![SKF 97541 [127729-35-5] Chemical Structure](data:image/png;base64,iVBORw0KGgoAAAANSUhEUgAAAAEAAAABCAQAAAC1HAwCAAAAC0lEQVR4nGP6zwAAAgcBApocMXEAAAAASUVORK5CYII= "SKF 97541 [127729-35-5]")
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Molecular Formula
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C4H12NO2P |
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InChiKey
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NHVRIDDXGZPJTJ-UHFFFAOYSA-N |
References for SKF 97541
References are publications that support the biological activity of the product
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Effects of GABAB receptor ligands in animal tests of depression and anxiety.
Frankowska M et al (2007)
Pharmacol Rep 59(6) : 645-55.
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Electrophysiological actions of GABAB agonists and antagonists in rat dorso-lateral septal neurones in vitro.
Bon C et al (1996)
Br J Pharmacol 118(4) : 961-7.
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Electrophysiological characterization of potent agonists and antagonists at pre- and postsynaptic GABAB receptors on neurones in rat brain slices.
Seabrook GR et al (1990)
Br J Pharmacol 101(4) : 949-57.
Potent GABAB receptor agonist
![SKF 97541 [127729-35-5] Chemical Structure](https://m2stage-v2.hellobio.com/media/catalog/product//h/b/hb0954.png "SKF 97541 [127729-35-5]")
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