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SKF 89976A hydrochloride product vial image | Hello Bio
SKF 89976A hydrochloride product vial image | Hello Bio
Biological Data
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Biological description
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Potent, selective and competitive GAT-1 GABA uptake inhibitor. Selective for GAT-1 over GAT-2, GAT-3 and BGT-1 (IC50 values are 0.13, 550, 944 and 7210 µM respectively). Inhibits GABA uptake (Ki = 7 µM) and transmitter-gated currents (Ki = 0.03 µM). Shows anticonvulsant actions. Blood-brain barrier permeable. |
Solubility & Handling
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Storage instructions
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+4°C (desiccate) |
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Solubility overview
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Soluble in water (100mM, gentle warming) or DMSO (100mM) |
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Important
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This product is for RESEARCH USE ONLY and is not intended for therapeutic or diagnostic use. Not for human or veterinary use. |
Chemical Data
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Chemical name
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1-(4,4-Diphenyl-3-butenyl)-3-piperidinecarboxylic acid hydrochloride |
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Chemical structure
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![SKF 89976A hydrochloride [85375-15-1] Chemical Structure](data:image/png;base64,iVBORw0KGgoAAAANSUhEUgAAAAEAAAABCAQAAAC1HAwCAAAAC0lEQVR4nGP6zwAAAgcBApocMXEAAAAASUVORK5CYII= "SKF 89976A hydrochloride [85375-15-1]")
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Molecular Formula
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C22H25NO2.HCl |
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PubChem identifier
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6917797 |
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SMILES
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Cl[H].OC(=O)C1CCCN(CC\C=C(\C2=CC=CC=C2)C2=CC=CC=C2)C1 |
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InChiKey
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SNGGBKYQZVAQKA-UHFFFAOYSA-N |
References for SKF 89976A hydrochloride
References are publications that support the biological activity of the product
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Identification and selective inhibition of the channel mode of the neuronal GABA transporter 1.
Krause S et al (2005)
Mol Pharmacol 68(6) : 1728-35.
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Orally active and potent inhibitors of gamma-aminobutyric acid uptake.
Ali FE et al (1985)
J Med Chem 28(5) : 653-60.
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Comparison of the anticonvulsant effects of two novel GABA uptake inhibitors and Ro 5-2807 in amygdaloid kindled rats.
Schwark WS et al (1985)
Naunyn Schmiedebergs Arch Pharmacol 329(4) : 367-71.
Potent, selective, competitive GAT-1 GABA uptake inhibitor
![SKF 89976A hydrochloride [85375-15-1] Chemical Structure](https://m2stage-v2.hellobio.com/media/catalog/product//h/b/hb0976.png "SKF 89976A hydrochloride [85375-15-1]")
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