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Biological Data
Biological description
p53-mitochondrial binding inhibitor which inhibits p53-mediated apoptosis. Also a HSP70 inhibitor. Supresses embroynic stem cell (eSC) self renewal.
By silencing p53, it may also increase human somatic cells to induced pluripotent stem cells (iPSCs) reprogramming efficiency.
Solubility & Handling
Storage instructions
+4°C
Solubility overview
Soluble in DMSO (100mM) or ethanol (100mM)
Important
This product is for RESEARCH USE ONLY and is not intended for therapeutic or diagnostic use. Not for human or veterinary use.
Chemical Data
Chemical name
2-Phenylethynesulfonamide
Chemical structure
Molecular Formula
C8 H7 NO2 S
PubChem identifier
327653
SMILES
NS(=O)(=O)C#CC1=CC=CC=C1
InChiKey
ZZUZYEMRHCMVTB-UHFFFAOYSA-N
References for Pifithrin-μ
References are publications that support the biological activity of the product
Prevention of chemotherapy-induced peripheral neuropathy by the small-molecule inhibitor pifithrin-μ.
Krukowski et al (2015)
Pain 156(11) : 2184-92
The HSP70 and autophagy inhibitor pifithrin-μ enhances the antitumor effects of TRAIL on human pancreatic cancer.
Monma et al (2013)
Mol Cancer Ther 12(4) : 341-51
Linking the p53 tumour suppressor pathway to somatic cell reprogramming.
Kawamura et al (2009)
Nature 460(7259) : 1140-4
p53 inhibitor. Supresses eSC self renewal and may increase stem cell reprogramming efficiency.
![Pifithrin-µ | [64984-31-2] Chemical Structure](https://m2stage-v2.hellobio.com/media/catalog/product//h/b/hb3025b.png "Pifithrin-µ | [64984-31-2]")
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