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Biological Data
Biological description
Aspartic protease inhibitor. Widely used as a research tool in studies of protease mechanisms and biological functions. Inhibits degradation of autophagic cargo inside autophagolysosomes.
Solubility & Handling
Storage instructions
+4°C
Important
This product is for RESEARCH USE ONLY and is not intended for therapeutic or diagnostic use. Not for human or veterinary use.
Chemical Data
Chemical structure
Molecular Formula
C34 H63 N5 O9
PubChem identifier
5478883
SMILES
O=C(N[C@@H](CC(C)C)[C@@H](O)CC(N[C@@H](C)C(N[C@H]([C@@H](O)CC(O)=O)CC(C)C)=O)=O)[C@H]([C@@H](C)C)NC([C@@H](NC(CC(C)C)=O)C(C)C)=O
InChiKey
FAXGPCHRFPCXOO-LXTPJMTPSA-N
Appearance
White to off-white powder
References for Pepstatin A
References are publications that support the biological activity of the product
Pepstatin A Alters Host Cell Autophagic Machinery and Leads to a Decrease in Influenza A Virus Production
Matarrese et al (2011)
J Cell Physiol 226(12) : 3368-77
Pepstatin A, an Aspartic Proteinase Inhibitor, Suppresses RANKL-induced Osteoclast Differentiation
Yoshida et al (2006)
J Biochem 139(3) : 583-90
Pepstatin, a New Pepsin Inhibitor Produced by Actinomycetes
Umezawa et al (1970)
J Antibiot (Tokyo) 23(5) : 259-62
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Aspartic protease inhibitor