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Images
Ouabain product vial image | Hello Bio
Ouabain product vial image | Hello Bio
Biological Data
Biological description
Selective Na+ / K+ ATPase inhibitor. Thought to act as a proliferative agent; promotes cardiac and vascular myocyte cell growth. Shows positive inotropic, vasoconstrictive and hypertensive actions.
Also shows antiviral activity (e.g. reported anti-MERS-CoV activity in Vero cells)
Solubility & Handling
Storage instructions
-20°C (desiccate)
Solubility overview
Soluble in water (10mM) and in DMSO (100mM)
Important
This product is for RESEARCH USE ONLY and is not intended for therapeutic or diagnostic use. Not for human or veterinary use.
Chemical Data
Chemical name
3-[(6-Deoxy-α-L-mannopyranosyl)oxy]-1,5,11α,14,19-pentahydoxycard-20(22)-enolide
Chemical structure
Molecular Formula
C29 H44 O12 .8H2 O
PubChem identifier
439501
SMILES
C[C@H]1[C@@H]([C@H]([C@H]([C@@H](O1)O[C@H]2C[C@H]([C@@]3([C@@H]4[C@@H](CC[C@@]3(C2)O)[C@]5(CC[C@@H]([C@]5(C[C@H]4O)C)C6=CC(=O)OC6)O)CO)O)O)O)O
InChi
InChI=1S/C29H44O12/c1-13-22(34)23(35)24(36)25(40-13)41-15-8-19(32)28(12-30)21-17(3-5-27(28,37)9-15)29(38)6-4-16(14-7-20(33)39-11-14)26(29,2)10-18(21)31/h7,13,15-19,21-25,30-32,34-38H,3-6,8-12H2,1-2H3/t13-,15-,16+,17+,18+,19+,21+,22-,23+,24+,25-,26+,27-,28
InChiKey
LPMXVESGRSUGHW-HBYQJFLCSA-N
References for Ouabain
References are publications that support the biological activity of the product
Screening of FDA-approved drugs using a MERS-CoV clinical isolate from South Korea identifies potential therapeutic options for COVID-19
Ko et al (2020)
bioRxiv : Preprint
Increased constrictor tone induced by ouabain treatment in rats.
Pulgar VM et al (2013)
J Cardiovasc Pharmacol 62(2) : 174-83.
Effect of m-calpain in PKCalpha-mediated proliferation of pulmonary artery smooth muscle cells by low dose of ouabain.
Shaikh S et al (2013)
Indian J Biochem Biophys 50(5) : 419-27.
Different roles of the cardiac Na+/Ca2+-exchanger in ouabain-induced inotropy, cell signaling, and hypertrophy.
Bai Y et al (2013)
Am J Physiol Heart Circ Physiol 304(3) : H427-35.
Selective Na+ / K+ ATPase inhibitor. Shows antiviral activity.
![Ouabain [630-60-4] Chemical Structure](https://m2stage-v2.hellobio.com/media/catalog/product//h/b/hb1140.png "Ouabain [630-60-4]")
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