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Biological Data
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Biological description
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Potent and selective JAK2 inhibitor (IC50 = 60 nM). Shows anti-neoplastic actions. |
Solubility & Handling
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Storage instructions
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-20°C |
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Solubility overview
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Soluble in DMSO (5mM, gentle warming) or ethanol (10mM) |
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Important
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This product is for RESEARCH USE ONLY and is not intended for therapeutic or diagnostic use. Not for human or veterinary use. |
Chemical Data
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Chemical name
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E-4,4'-(1,2-Diethyl-1,2-ethenediyl)bis[2-[(diethylamino)methyl]phenol |
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Chemical structure
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![NSC 33994 [82058-16-0] Chemical Structure](data:image/png;base64,iVBORw0KGgoAAAANSUhEUgAAAAEAAAABCAQAAAC1HAwCAAAAC0lEQVR4nGP6zwAAAgcBApocMXEAAAAASUVORK5CYII= "NSC 33994 [82058-16-0]")
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Molecular Formula
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C28H42N2O2 |
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PubChem identifier
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5473838 |
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SMILES
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CC/C(C2=CC=C(O)C(CN(CC)CC)=C2)=C(CC)\C1=CC(CN(CC)CC)=C(O)C=C1 |
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InChiKey
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QFNJFVBKASKGEU-OCEACIFDSA-N |
References for NSC 33994
References are publications that support the biological activity of the product
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The Jak2 small molecule inhibitor, G6, reduces the tumorigenic potential of T98G glioblastoma cells in vitro and in vivo.
Baskin R et al (2014)
PLoS One 9(8) : e105568.
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The Jak2 inhibitor, G6, alleviates Jak2-V617F-mediated myeloproliferative neoplasia by providing significant therapeutic efficacy to the bone marrow.
Kirabo A et al (2011)
Neoplasia 13(11) : 1058-68.
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Identification of a novel inhibitor of JAK2 tyrosine kinase by structure-based virtual screening.
Kiss R et al (2009)
Bioorg Med Chem Lett 19(13) : 3598-601.
Potent, selective JAK2 inhibitor
![NSC 33994 [82058-16-0] Chemical Structure](https://m2stage-v2.hellobio.com/media/catalog/product//h/b/hb1430.png "NSC 33994 [82058-16-0]")
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