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Biological Data
Biological description
Non-selective, competitive, cell permeable cAMP and cGMP PDE inhibitor, competitive, non-specific cAMP and cGMP phosphodiesterase inhibitor which increases cAMP levels. IBMX also enhances 3T3-L1 cell differentiation and promotes neural progenitor cell differentiation.
Solubility & Handling
Storage instructions
+4°C
Solubility overview
Soluble in DMSO (75 mM), and in ethanol (50 mM)
Important
This product is for RESEARCH USE ONLY and is not intended for therapeutic or diagnostic use. Not for human or veterinary use.
Chemical Data
Chemical name
3,7-Dihydro-1-methyl-3-(2-methylpropyl)-1H-purine-2,6-dione
Chemical structure
Molecular Formula
C10 H14 N4 O2
SMILES
CC(C)CN1C2=C(C(=O)N(C1=O)C)NC=N2
InChi
InChI=1S/C10H14N4O2/c1-6(2)4-14-8-7(11-5-12-8)9(15)13(3)10(14)16/h5-6H,4H2,1-3H3,(H,11,12)
InChiKey
APIXJSLKIYYUKG-UHFFFAOYSA-N
Appearance
White to off-white solid
References for IBMX
References are publications that support the biological activity of the product
cAMP promotes the differentiation of neural progenitor cells in vitro via modulation of voltage-gated calcium channels.
Lepski et al (2013)
Front Cell Neurosci. 19 : 7:155
Phosphodiesterase inhibitor 3-isobutyl-methyl-xanthine affects rabbit ovaries and oviduct.
Sirotkin et al (2010)
Eur J Pharmacol 643(1) : 145-51
Phosphodiesterase inhibitors suppress alpha2-adrenoceptor-mediated 5-hydroxytryptamine release from tracheae of newborn rabbits.
Freitag et al (1998)
Eur J Pharmacol 354(1) : 67-71
Publications
These publications cite the use of IBMX purchased from Hello Bio:
Presynaptic cGMP sets synaptic strength in the striatum and is important for motor learning
Fieblinger T et al (2022)
EMBO Rep 23(8) : e54361
PACmn for improved optogenetic control of intracellular cAMP
Yang S et al (2021)
BMC Biol 19(1) : 227
Non-selective, competitive cAMP and cGMP PDE inhibitor. Facilitates neural progenitor cell differentiation.
![IBMX [28822-58-4] Chemical Structure](https://m2stage-v2.hellobio.com/media/catalog/product//h/b/hb3000_3.png "IBMX [28822-58-4]")
Understanding purity and quality - a guide for life scientists 
