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Biological Data
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Biological description
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Nucleoside analog which resembles Deoxycytidine and inhibits DNA synthesis and repair.
Shows anticancer and antitumor activity.
Also inhibits MERS-CoV and SARS-CoV in vitro (EC50 values are 1.2 and 4.9 µM, respectively). |
Solubility & Handling
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Storage instructions
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+4°C |
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Solubility overview
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Soluble in water (100 mM), and in DMSO (20 mM) |
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Important
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This product is for RESEARCH USE ONLY and is not intended for therapeutic or diagnostic use. Not for human or veterinary use |
Chemical Data
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Chemical name
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(+)-2'-Deoxy-2',2'-difluorocytidine hydrochloride |
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Chemical structure
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![Gemcitabine hydrochloride [122111-03-9] Chemical Structure](data:image/png;base64,iVBORw0KGgoAAAANSUhEUgAAAAEAAAABCAQAAAC1HAwCAAAAC0lEQVR4nGP6zwAAAgcBApocMXEAAAAASUVORK5CYII= "Gemcitabine hydrochloride [122111-03-9]")
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Molecular Formula
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C9H11F2N3O4.HCl |
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PubChem identifier
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69101485 |
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SMILES
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OC[C@@H]1[C@@H](O)C(F)(F)[C@H](N2C(N=C(N)C=C2)=O)O1.Cl |
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InChi
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InChI=1S/C9H11F2N3O4.ClH/c10-9(11)6(16)4(3-15)18-7(9)14-2-1-5(12)13-8(14)17;/h1-2,4,6-7,15-16H,3H2,(H2,12,13,17);1H/t4-,6-,7-;/m1./s1 |
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InChiKey
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OKKDEIYWILRZIA-OSZBKLCCSA-N |
References for Gemcitabine hydrochloride
References are publications that support the biological activity of the product
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Repurposing of clinically developed drugs for treatment of Middle East respiratory syndrome coronavirus infection
Dyall et al (2014)
Antimicrob Agents Chemother 58(8) : 4885-93
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The role of gemcitabine in the treatment of other tumours
Carmichael (1998)
BR J Cancer. 78 : 21-5
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Gemcitabine: a modulator of intracellular nucleotide and deoxynucleotide metabolism
Heinemann et al (1995)
Semin Oncol. 22 : 11-8
DNA synthesis and repair inhibitor
![Gemcitabine hydrochloride [122111-03-9] Chemical Structure](https://m2stage-v2.hellobio.com/media/catalog/product//h/b/hb4199_1.png "Gemcitabine hydrochloride [122111-03-9]")
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