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Biological Data
Biological description
FCCP is an protonophore which is widely used to investigate the role of mitochondria in cellular function.
FCCP also induces apoptosis.
CCCP is also available.
Solubility & Handling
Storage instructions
Room temperature
Solubility overview
Soluble in DMSO (100 mM)
Important
This product is for RESEARCH USE ONLY and is not intended for therapeutic or diagnostic use. Not for human or veterinary use
Chemical Data
Chemical name
Carbonyl cyanide 4-(trifluoromethoxy)phenylhydrazone
Chemical structure
Molecular Formula
C10 H5 F3 N4 O
SMILES
C1=CC(=CC=C1NN=C(C#N)C#N)OC(F)(F)F
InChi
InChI=1S/C10H5F3N4O/c11-10(12,13)18-9-3-1-7(2-4-9)16-17-8(5-14)6-15/h1-4,16H
InChiKey
BMZRVOVNUMQTIN-UHFFFAOYSA-N
References for FCCP
References are publications that support the biological activity of the product
Mitochondrial uncoupler FCCP activates proton conductance but does not block store-operated Ca(2+) current in liver cells.
MS et al (2010)
Arch Biochem Biophys 495(2) : 152-8
Mitochondrial uncoupling, with low concentration FCCP, induces ROS-dependent cardioprotection independent of KATP channel activation.
Brennan et al (2006)
Cardiovasc Res. 72(2) : 313-21
FCCP depolarizes plasma membrane potential by activating proton and Na+ currents in bovine aortic endothelial cells.
Park et al (2002)
Pflugers Arch 443(3) : 344-52
Potent uncoupler of mitochondrial oxidative phosphorylation.
![FCCP [370-86-5] Chemical Structure](https://m2stage-v2.hellobio.com/media/catalog/product//h/b/hb2903_1.png "FCCP [370-86-5]")
