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Biological Data
Biological description
Na+ / K+ ATPase α subunit inhibitor (IC50 = 2.69 µM) which increases regulator of G protein signaling 2 (RGS2) protein levels (EC50 = 83 nM). Exhibits little or no effect on RGS4. Also potent HIV-1 replication inhibitor and exhibits anti-MERS-CoV activity in Vero cells in vitro.
Solubility & Handling
Storage instructions
Room temperature
Solubility overview
Soluble in DMSO (100mM)
Important
This product is for RESEARCH USE ONLY and is not intended for therapeutic or diagnostic use. Not for human or veterinary use.
Chemical Data
Chemical name
4-[(3S,5R,8R,9S,10S,12R,13S,14S)-3-[(2S,4S,5R,6R)-5-[(2S,4S,5R,6R)-5-[(2S,4S,5R,6R)-4,5-dihydroxy-6-methyl-oxan-2-yl]oxy-4-hydroxy-6-methyl-oxan-2-yl]oxy-4-hydroxy-6-methyl-oxan-2-yl]oxy-12,14-dihydroxy-10,13-dimethyl-1,2,3,4,5,6,7,8,9,11,12,15,16,17-tetradecahydrocyclopenta[a]phenanthren-17-yl]-5H-furan-2-one
Chemical structure
Molecular Formula
C41H64O14
PubChem identifier
2724385
SMILES
O=C\1OC/C(=C/1)[C@H]2CC[C@@]8(O)[C@]2(C)[C@H](O)C[C@H]7[C@H]8CC[C@H]6[C@]7(C)CC[C@H](O[C@@H]5O[C@H](C)[C@@H](O[C@@H]4O[C@@H]([C@@H](O[C@@H]3O[C@@H]([C@@H](O)[C@@H](O)C3)C)[C@@H](O)C4)C)[C@@H](O)C5)C6
InChi
InChI=1S/C41H64O14/c1-19-36(47)28(42)15-34(50-19)54-38-21(3)52-35(17-30(38)44)55-37-20(2)51-33(16-29(37)43)53-24-8-10-39(4)23(13-24)6-7-26-27(39)14-31(45)40(5)25(9-11-41(26,40)48)22-12-32(46)49-18-22/h12,19-21,23-31,33-38,42-45,47-48H,6-11,13-18H2,1-5H3/t
InChiKey
LTMHDMANZUZIPE-PUGKRICDSA-N
References for Digoxin
References are publications that support the biological activity of the product
Drug repurposing for new, efficient, broad spectrum antivirals
Pacheco et al (2019)
VIrus Res. 264 : 22-31
Digoxin suppresses HIV-1 replication by altering viral RNA processing.
Wong RW et al (2013)
PLoS Pathog 9(3) : e1003241.
Cardiotonic steroids stabilize regulator of G protein signaling 2 protein levels.
Sjögren B et al (2012)
Mol Pharmacol 82(3) : 500-9.
Digoxin in the management of cardiovascular disorders.
Gheorghiade M et al (2004)
Circulation 109(24) : 2959-64.
Inhibition of Na,K-ATPase by oleandrin and oleandrigenin, and their detection by digoxin immunoassays.
Jortani SA et al (1996)
Clin Chem 42(10) : 1654-8.
Na+ / K+ ATPase α subunit inhibitor. Antiviral.
![Digoxin [20830-75-5] Chemical Structure](https://m2stage-v2.hellobio.com/media/catalog/product//h/b/hb1138.png "Digoxin [20830-75-5]")
Understanding purity and quality - a guide for life scientists 
