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Images
Dexamethasone product vial image | Hello Bio
Dexamethasone product vial image | Hello Bio
Biological Data
Biological description
Synthetic glucocorticoid. Differentiates mesenchymal stem cells (MSCs) into adipogenic, chondrogenic and osteogenic lineages.
Commonly used with ascorbic acid and β-Gly for osteogenic differentiation of stem cells.
Also shows potent anti-inflammatory and immunospressant effects. Active in vivo .
Recently investigated as part of COVID-19 compound repurposing.
Apoptosis inducer.
Water soluble dexamethasone also available.
Solubility & Handling
Storage instructions
-20°C (protect from light)
Solubility overview
Soluble in DSMO (100mM)
Important
This product is for RESEARCH USE ONLY and is not intended for therapeutic or diagnostic use. Not for human or veterinary use.
Chemical Data
Chemical name
(11β,16α)-9-Fluoro-11,17,21-trihydroxy-16-methyl-pregna-1,4-diene-3,20-dione
Chemical structure
Molecular Formula
C22 H29 FO5
SMILES
C[C@@H]1C[C@H]2[C@@H]3CCC4=CC(=O)C=C[C@@]4([C@]3([C@H](C[C@@]2([C@]1(C(=O)CO)O)C)O)F)C
InChi
InChI=1S/C22H29FO5/c1-12-8-16-15-5-4-13-9-14(25)6-7-19(13,2)21(15,23)17(26)10-20(16,3)22(12,28)18(27)11-24/h6-7,9,12,15-17,24,26,28H,4-5,8,10-11H2,1-3H3/t12-,15+,16+,17+,19+,20+,21+,22+/m1/s1
InChiKey
UREBDLICKHMUKA-CXSFZGCWSA-N
References for Dexamethasone
References are publications that support the biological activity of the product
Dexamethasone alleviates tumor-associated brain damage and angiogenesis.
Fan Z et al (2014)
PLoS One 9(4) : e93264.
Short bouts of mechanical loading are as effective as dexamethasone at inducing matrix production by human bone marrow mesenchymal stem cell.
Sittichokechaiwut A et al (2010)
Eur Cell Mater 20 : 45-57.
Glucocorticoid receptor antagonism by cyproterone acetate and RU486.
Honer C et al (2003)
Mol Pharmacol 63(5) : 1012-20.
Publications
These publications cite the use of Dexamethasone purchased from Hello Bio:
Chronic intermittent ethanol exposure disrupts stress-related tripartite communication to impact affect-related behavioral selection in male rats.
Munier JJ et al (2023)
Neurobiology of stress 24 : 100539
Anti-inflammatory synthetic glucocorticoid. Induces hMSC differentiation. Apoptosis inducer.
![Dexamethasone [50-02-2] Chemical Structure](https://m2stage-v2.hellobio.com/media/catalog/product//h/b/hb2521.png "Dexamethasone [50-02-2]")
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