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Biological Data
Biological description
STAT3 inhibitor (IC50 = 4.6 µM). Also inhibits human acetylcholinesterase (AChE), butyrylcholinesterase (BuChE) and SHP2 (IC50 values are 4.09, 6.38 and 22.5 µM respectively). Shows anti-Alzheimer's disease, anticancer, antidiabetic and antiobesity actions.
Solubility & Handling
Storage instructions
Room temperature
Solubility overview
Soluble in DMSO (10mM)
Important
This product is for RESEARCH USE ONLY and is not intended for therapeutic or diagnostic use. Not for human or veterinary use.
Chemical Data
Chemical name
1,2,6,7,8,9-Hexahydro-1,6,6-trimethyl[1,2-b ]furan-10,11-dione
Chemical structure
Molecular Formula
C19 H20 O3
PubChem identifier
160254
SMILES
O=C(C1=C(C4=C3[C@@H](C)CO4)C=CC2=C1CCCC(C)2C)C3=O
InChiKey
GVKKJJOMQCNPGB-JTQLQIEISA-N
References for Cryptotanshinone
References are publications that support the biological activity of the product
Inhibitory effect of cryptotanshinone on angiogenesis and Wnt/β-catenin signaling pathway in human umbilical vein endothelial cells.
Chen Q et al (2014)
Chin J Integr Med 20(10) : 743-50.
Cryptotanshinone, an acetylcholinesterase inhibitor from Salvia miltiorrhiza, ameliorates scopolamine-induced amnesia in Morris water maze task.
Wong KK et al (2010)
Planta Med 76(3) : 228-34.
Cryptotanshinone inhibits constitutive signal transducer and activator of transcription 3 function through blocking the dimerization in DU145 prostate cancer cells.
Shin DS et al (2009)
Cancer Res 69(1) : 193-202.
Antidiabetes and antiobesity effect of cryptotanshinone via activation of AMP-activated protein kinase.
Kim EJ et al (2007)
Mol Pharmacol 72(1) : 62-72.
![Cryptotanshinone [35825-57-1] Chemical Structure](https://m2stage-v2.hellobio.com/media/catalog/product//h/b/hb1434.png "Cryptotanshinone [35825-57-1]")
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