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Biological Data
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Biological description
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Cell permeable, potent, selective, non-transition state and non-competitive gamma-secretase inhibitor. Notch processing inhibitor. Only weakly affects presenilinase activity.
Please note this item is not for sale in Canada |
Solubility & Handling
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Storage instructions
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+4°C |
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Important
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This product is for RESEARCH USE ONLY and is not intended for therapeutic or diagnostic use. Not for human or veterinary use |
Chemical Data
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Chemical name
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(2S)-2-([(3,5-Difluorophenyl)acetyl]amino)-N-[(3S)-1-methyl-2-oxo-5-phenyl-2,3-dihydro-1H-1,4-benzodiazepin-3-yl]propanamide |
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Chemical structure
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![Compound E [209986-17-4] Chemical Structure](data:image/png;base64,iVBORw0KGgoAAAANSUhEUgAAAAEAAAABCAQAAAC1HAwCAAAAC0lEQVR4nGP6zwAAAgcBApocMXEAAAAASUVORK5CYII= "Compound E [209986-17-4]")
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Molecular Formula
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C27H24F2N4O3 |
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PubChem identifier
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11306390 |
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SMILES
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C[C@@H](C(N[C@H]1N=C(C2=CC=CC=C2N(C1=O)C)C3=CC=CC=C3)=O)NC(CC4=CC(F)=CC(F)=C4)=O |
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InChiKey
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JNGZXGGOCLZBFB-IVCQMTBJSA-N |
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Appearance
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White to off-white solid |
Potent, selective, non-competitive γ-secretase inhibitor. Induces neuronal differentiation.
![Compound E [209986-17-4] Chemical Structure](https://m2stage-v2.hellobio.com/media/catalog/product//h/b/hb3849.png "Compound E [209986-17-4]")
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