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CGP 54626 hydrochloride product vial image | Hello Bio
CGP 54626 hydrochloride product vial image | Hello Bio
Biological Data
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Biological description
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Potent and selective GABAB receptor antagonist (IC50 = 4 nM). |
Solubility & Handling
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Storage instructions
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Room temperature |
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Solubility overview
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Soluble in DMSO (50mM, gentle warming) or ethanol (10mM) |
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Important
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This product is for RESEARCH USE ONLY and is not intended for therapeutic or diagnostic use. Not for human or veterinary use. |
Chemical Data
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Chemical name
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[S-(R*,R*)]-[3-[[1-(3,4-Dichlorophenyl)ethyl]amino]-2-hydroxypropyl](cyclohexylmethyl) phosphinic acid |
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Chemical structure
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![CGP 54626 hydrochloride [149184-21-4] Chemical Structure](data:image/png;base64,iVBORw0KGgoAAAANSUhEUgAAAAEAAAABCAQAAAC1HAwCAAAAC0lEQVR4nGP6zwAAAgcBApocMXEAAAAASUVORK5CYII= "CGP 54626 hydrochloride [149184-21-4]")
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Molecular Formula
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C18H28Cl2NO3P.HCl |
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PubChem identifier
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197583 |
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SMILES
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OP(CC1CCCCC1)(C[C@@H](O)CN[C@@H](C)C2=CC(Cl)=C(Cl)C=C2)=O.Cl |
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InChi
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InChI=1S/C18H28Cl2NO3P.ClH/c1-13(15-7-8-17(19)18(20)9-15)21-10-16(22)12-25(23,24)11-14-5-3-2-4-6-14;/h7-9,13-14,16,21-22H,2-6,10-12H2,1H3,(H,23,24);1H/t13-,16-;/m0./s1 |
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InChiKey
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ZQCFHOVIXCJPLE-LINSIKMZSA-N |
References for CGP 54626 hydrochloride
References are publications that support the biological activity of the product
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GABAB receptor-mediated tonic inhibition of noradrenergic A7 neurons in the rat.
Wu Y et al (2011)
J Neurophysiol 105(6) : 2715-28.
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Characterization of the binding of [3H]CGP54626 to GABAB receptors in the male bullfrog (Rana catesbeiana)
Asay et al. (2006)
Brain Res. (1) : 76-85.
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GABA(B)-receptor subtypes assemble into functional heteromeric complexes
Kaupmann et al (1998)
Nature. 683-7 : 3712
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Binding characteristics of gamma-hydroxybutyric acid as a weak but selective GABAB receptor agonist.
Mathivet P et al (1997)
Eur J Pharmacol 321(1) : 67-75.
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The action of new potent GABAB receptor antagonists in the hemisected spinal cord preparation of the rat
Brugger et al (1993)
Eur J Pharmacol. (1) : 153-5
Potent, selective GABAB receptor antagonist
![CGP 54626 hydrochloride [149184-21-4] Chemical Structure](https://m2stage-v2.hellobio.com/media/catalog/product//h/b/hb0959.png "CGP 54626 hydrochloride [149184-21-4]")
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