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Biological Data
Biological description
Selective M1 muscarinic receptor agonist. Shows memory enhancing actions.
Solubility & Handling
Storage instructions
-20°C
Solubility overview
Soluble in water (75mM) and in DMSO (50mM)
Important
This product is for RESEARCH USE ONLY and is not intended for therapeutic or diagnostic use. Not for human or veterinary use
Chemical Data
Chemical name
cis -2-Methylspiro[1,3-oxathiolane-5 ,3'-quinuclidine] hydrochloride
Chemical structure
Molecular Formula
C10 H17 NOS.HCl
PubChem identifier
9837584
SMILES
CC1OC2(CN3CCC2CC3)CS1.Cl
InChi
InChI=1S/C10H17NOS.ClH/c1-8-12-10(7-13-8)6-11-4-2-9(10)3-5-11;/h8-9H,2-7H2,1H3;1H
InChiKey
SURWTGAXEIEOGY-UHFFFAOYSA-N
References for Cevimeline hydrochloride
References are publications that support the biological activity of the product
NGF-dependent neurotrophic-like effects of AF102B, an M1 muscarinic agonist, in PC12M1 cells.
Gurwitz D et al (1995)
Neuroreport 6(3) : 485-8.
L-689,660, a novel cholinomimetic with functional selectivity for M1 and M3 muscarinic receptors.
Hargreaves RJ et al (1992)
Br J Pharmacol 107(2) : 494-501.
(+-)-cis-2-methyl-spiro(1,3-oxathiolane-5,3')quinuclidine, an M1 selective cholinergic agonist, attenuates cognitive dysfunctions in an animal model of Alzheimer's disease.
Fisher A et al (1991)
J Pharmacol Exp Ther 257(1) : 392-403.
Selective M1 receptor agonist
![Cevimeline hydrochloride [107220-28-0] Chemical Structure](https://m2stage-v2.hellobio.com/media/catalog/product//h/b/hb1490.png "Cevimeline hydrochloride [107220-28-0]")
Understanding purity and quality - a guide for life scientists