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Biological Data
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Biological description
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Calmodulin (CaM) antagonist. Inhibits calmodulin-dependent phosphodiesterase (IC50 = 0.15 µM). Antagonises Ca2+-transporting ATPase calmodulin-induced activation (IC50 = 0.35 µM). Inhibits adenylyl cyclase, soluble fusion protein, ACIX and ACV-ACII fusion proteins. Blocks L-type calcium channels as well as voltage-dependent Na+ and K+ channel currents; increases intracellular calcium. Shows cytotoxic and apoptotic effects. |
Solubility & Handling
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Storage instructions
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+4°C |
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Solubility overview
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Soluble in DMSO (100mM) or ethanol (100mM) |
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Important
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This product is for RESEARCH USE ONLY and is not intended for therapeutic or diagnostic use. Not for human or veterinary use. |
Chemical Data
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Chemical name
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1-[Bis(4-chlorophenyl)methyl]-3-[2- (2,4-dichlorophenyl)-2-(2,4-dichlorobenzyloxy)ethyl]-1H-imidazolium chloride |
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Chemical structure
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![Calmidazolium Chloride [57265-65-3] Chemical Structure](data:image/png;base64,iVBORw0KGgoAAAANSUhEUgAAAAEAAAABCAQAAAC1HAwCAAAAC0lEQVR4nGP6zwAAAgcBApocMXEAAAAASUVORK5CYII= "Calmidazolium Chloride [57265-65-3]")
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Molecular Formula
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C31H23Cl7N2O |
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PubChem identifier
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644274 |
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SMILES
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C1=CC(=CC=C1C(C2=CC=C(C=C2)Cl)N3C=C[N+](=C3)CC(C4=C(C=C(C=C4)Cl)Cl)OCC5=C(C=C(C=C5)Cl)Cl)Cl.[Cl-] |
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InChiKey
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YGEIMSMISRCBFF-UHFFFAOYSA-M |
References for Calmidazolium Chloride
References are publications that support the biological activity of the product
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Cardiotoxicity of calmidazolium chloride is attributed to calcium aggravation, oxidative and nitrosative stress, and apoptosis.
Kumar S et al (2009)
Free Radic Biol Med 47(6) : 699-709.
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Small ligands modulating the activity of mammalian adenylyl cyclases: a novel mode of inhibition by calmidazolium.
Haunsø A et al (2003)
Mol Pharmacol 63(3) : 624-31.
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Comparison of the calmodulin antagonists compound 48/80 and calmidazolium.
Gietzen K (1983)
Biochem J 216(3) : 611-6.
Calmodulin (CaM) antagonist
![Calmidazolium Chloride [57265-65-3] Chemical Structure](https://m2stage-v2.hellobio.com/media/catalog/product//h/b/hb0156.png "Calmidazolium Chloride [57265-65-3]")
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