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Images
Ascomycin product vial image | Hello Bio
Ascomycin product vial image | Hello Bio
Biological Data
Biological description
Calcineurin phosphatase inhibitor that binds to FK 506-binding protein 12 (FKBP12) (IC50 = 49 nM). Also suppresses T-cells (IC50 = 3.9 nM). Displays neurogenerative, neuroprotective and anticonvulsant properties.
Solubility & Handling
Storage instructions
-20°C
Solubility overview
Soluble in DMSO (50mM) or ethanol (50mM)
Important
This product is for RESEARCH USE ONLY and is not intended for therapeutic or diagnostic use. Not for human or veterinary use.
Chemical Data
Chemical name
(3S ,4R ,5S ,8R ,9E ,12S ,14S ,15R ,16S ,18R ,19R ,26aS )-8-Ethyl-5,6,8,11,12,13,14,15,16,17,18,1 9,24,25,26,26a-hexadecahydro-5,19-dihydroxy-3-[(1E )-2-[(1R ,3R ,4R )-4-hydroxy-3-methoxycyclohexyl]-1-methylethenyl]-14,16-dimethoxy-4,10,12,18-tetrameth yl-15,19-epoxy-3H -pyrido[2,1-c ][1,4]oxaazacyclotricosine-1,7,20,21(4H ,23H )tetrone
Chemical structure
Molecular Formula
C43 H69 NO12
PubChem identifier
5282071
SMILES
O[C@H]1[C@H](OC)C[C@H](/C=C(C)/[C@@H](O4)[C@H](C)[C@@H](O)CC([C@H](CC)/C=C(C)/C[C@H](C)C[C@H](OC)[C@@]2([H])O[C@](C(C(N3[C@@](C4=O)([H])CCCC3)=O)=O)(O)[C@H](C)C[C@@H]2OC)=O)CC1
InChiKey
ZDQSOHOQTUFQEM-NURRSENYSA-N
References for Ascomycin
References are publications that support the biological activity of the product
Ascomycin and FK506: pharmacology and therapeutic potential as anticonvulsants and neuroprotectants.
Sierra-Paredes G et al (2008)
CNS Neurosci Ther 14(1) : 36-46.
Anticonvulsant effect of the calcineurin inhibitor ascomycin on seizures induced by picrotoxin microperfusion in the rat hippocampus.
Vázquez-López A et al (2006)
Pharmacol Biochem Behav 84(3) : 511-6.
Genetically engineered analogs of ascomycin for nerve regeneration.
Revill WP et al (2002)
J Pharmacol Exp Ther 302(3) : 1278-85.
Calcineurin phosphatase inhibitor
![Ascomycin [104987-12-4] Chemical Structure](https://m2stage-v2.hellobio.com/media/catalog/product//h/b/hb0123.png "Ascomycin [104987-12-4]")
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