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Biological Data
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Biological description
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Semi-synthetic, water soluble Artemisinin derivative. Inhibits vascular endothelial proliferation (IC50 = 25 µM) and activates p38 MAPK. Displays antimalarial, antiangiogenic, antiviral and anticancer properties. |
Solubility & Handling
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Storage instructions
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+4°C |
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Solubility overview
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Soluble in DMSO (25mg/ml) or ethanol (25mg/ml) |
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Important
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This product is for RESEARCH USE ONLY and is not intended for therapeutic or diagnostic use. Not for human or veterinary use. |
Chemical Data
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Chemical structure
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![Artesunate [88495-63-0] Chemical Structure](data:image/png;base64,iVBORw0KGgoAAAANSUhEUgAAAAEAAAABCAQAAAC1HAwCAAAAC0lEQVR4nGP6zwAAAgcBApocMXEAAAAASUVORK5CYII= "Artesunate [88495-63-0]")
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Molecular Formula
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C19H28O8 |
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PubChem identifier
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16394563 |
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SMILES
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C[C@@H]1CC[C@H]2[C@@H](C)[C@H](O[C@@H]3OC4(C)CC[C@@H]1[C@@]23OO4)OC(=O)CCC(O)=O |
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InChi
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1S/C19H28O8/c1-10-4-5-13-11(2)16(23-15(22)7-6-14(20)21)24-17-19(13)12(10)8-9-18(3,25-17)26-27-19/h10-13,16-17H,4-9H2,1-3H3,(H,20,21)/t10-,11-,12+,13+,16+,17-,18?,19-/m1/s1 |
References for Artesunate
References are publications that support the biological activity of the product
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Supergenomic network compression and the discovery of EXP1 as a glutathione transferase inhibited by artesunate.
Lisewski AM et al (2014)
Cell 158(4) : 916-28.
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Safety and efficacy field study of artesunate for dogs with non-resectable tumours.
Rutteman GR et al (2013)
Anticancer Res 33(5) : 1819-27.
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The artemisinin derivative artesunate inhibits corneal neovascularization by inducing ROS-dependent apoptosis in vascular endothelial cells.
Cheng R et al (2013)
Invest Ophthalmol Vis Sci 54(5) : 3400-9.
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The antiviral activities of artemisinin and artesunate.
Efferth T et al (2008)
Clin Infect Dis 47(6) : 804-11.
Semi-synthetic, water soluble Artemisinin derivative
![Artesunate [88495-63-0] Chemical Structure](https://m2stage-v2.hellobio.com/media/catalog/product//h/b/hb0122.png "Artesunate [88495-63-0]")
Understanding purity and quality - a guide for life scientists