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Biological Data
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Biological description
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Plasmodium falciparum SERCA orthologue (PfATP6) inhibitor (Ki = 150 nM). Thought to generate cytotoxic C-radicals. Shows anti-malarial, anti-proliferative and anti-neoplastic actions. |
Solubility & Handling
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Storage instructions
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+4°C |
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Solubility overview
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Soluble in DMSO (100mM) or ethanol (75mM) |
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Important
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This product is for RESEARCH USE ONLY and is not intended for therapeutic or diagnostic use. Not for human or veterinary use. |
Chemical Data
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Chemical name
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(3R,5aS,6R,8aS,9R,12S,12aR)-Octahydro-3,6,9-trimethyl-3,12-epoxy-12H-pyrano[4,3-j]-1, 2-benzodioxepin-10(3H)-one |
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Chemical structure
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![Artemisinin [63968-64-9] Chemical Structure](data:image/png;base64,iVBORw0KGgoAAAANSUhEUgAAAAEAAAABCAQAAAC1HAwCAAAAC0lEQVR4nGP6zwAAAgcBApocMXEAAAAASUVORK5CYII= "Artemisinin [63968-64-9]")
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Molecular Formula
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C15H22O5 |
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SMILES
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O=C1O[C@]([H])(O[C@@](OO4)(C)CC3)[C@]24[C@](CC[C@@H](C)[C@]32[H])([H])[C@H]1C |
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InChiKey
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BLUAFEHZUWYNDE-NNWCWBAJSA-N |
References for Artemisinin
References are publications that support the biological activity of the product
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Artemisinin inhibits neuroblastoma proliferation through activation of AHP-activated protein kinase (AMPK) signaling.
Tan WQ et al (2014)
Pharmazie 69(6) : 468-72.
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Considerations on the mechanism of action of artemisinin antimalarials: part 1--the 'carbon radical' and 'heme' hypotheses.
Haynes RK et al (2013)
Infect Disord Drug Targets 13(4) : 217-77.
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Artemisinins target the SERCA of Plasmodium falciparum.
Eckstein-Ludwig U et al (2003)
Nature 424(6951) : 957-61.
Plasmodium falciparum SERCA orthologue inhibitor
![Artemisinin [63968-64-9] Chemical Structure](https://m2stage-v2.hellobio.com/media/catalog/product//h/b/hb1115.png "Artemisinin [63968-64-9]")
Understanding purity and quality - a guide for life scientists