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Biological Data
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Biological description
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Potent calmodulin antagonist. Cell permeable. Napthalenesulfonamide W-7 analog. Inhibits calmodulin activated PDE activity (IC50 = 3 µM). |
Solubility & Handling
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Storage instructions
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Room temperature |
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Solubility overview
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Soluble in DMSO (50mM) |
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Important
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This product is for RESEARCH USE ONLY and is not intended for therapeutic or diagnostic use. Not for human or veterinary use. |
Chemical Data
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Chemical name
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N-(10-Aminodecyl)-5-chloro-1-naphthalenesulfonamide hydrochloride |
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Chemical structure
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![A-7 hydrochloride [79127-24-5] Chemical Structure](data:image/png;base64,iVBORw0KGgoAAAANSUhEUgAAAAEAAAABCAQAAAC1HAwCAAAAC0lEQVR4nGP6zwAAAgcBApocMXEAAAAASUVORK5CYII= "A-7 hydrochloride [79127-24-5]")
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Molecular Formula
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C20H29ClN2O2S.HCl |
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PubChem identifier
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44119113 |
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SMILES
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C1=CC2=C(C=CC=C2Cl)C(=C1)S(=O)(=O)NCCCCCCCCCCN.Cl |
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InChiKey
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XDJCAQBTSCRBHS-UHFFFAOYSA-N |
References for A-7 hydrochloride
References are publications that support the biological activity of the product
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Direct interaction of calmodulin antagonists with Ca2+/calmodulin-dependent cyclic nucleotide phosphodiesterase.
Itoh H et al (1984)
J Biochem 96(6) : 1721-6.
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Naphthalenesulfonamides as calmodulin antagonists.
Hidaka H et al (1983)
Methods Enzymol 102 : 185-94.
Potent, cell-permeable calmodulin (CaM) antagonist
![A-7 hydrochloride [79127-24-5] Chemical Structure](https://m2stage-v2.hellobio.com/media/catalog/product//h/b/hb0097.png "A-7 hydrochloride [79127-24-5]")
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