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Images
Calcium Ionophore A23187 product vial image | Hello Bio
Calcium Ionophore A23187 product vial image | Hello Bio
Biological Data
Biological description
Non-selective calcium ionophore which facilitates transport of Ca 2+ across the plasma membrane.
Increases intracellular Ca2+ concentration to induce Ca2+ -dependent cell death. Also increases Zn2+ and Fe2+ permeability across the cell membrane.
Induces ROS and oxidative platelet particle formation.
Also activates IKK2 and NF-κB in mast cells, induces cytokine production and degranulation.
Additionally shown to induce apoptosis and autophagy.
Solubility & Handling
Storage instructions
+4°C (desiccate)
Solubility overview
Soluble in DMSO (50mM) and in ethanol (10mM, gentle warming)
Important
This product is for RESEARCH USE ONLY and is not intended for therapeutic or diagnostic use. Not for human or veterinary use.
Chemical Data
Chemical name
5-(Methylamino)-2-[[2R ,3R ,6S ,8S ,9R ,11R )-3,9,11-trimethyl-8-[(1S )-1-methyl-2-oxo-2-(1H -pyr rol-2-yl)-ethyl]-1,7-dioxaspiro[5.5]undec-2-yl]methyl]-4-benzoxazolecarboxylic acid
Chemical structure
Molecular Formula
C29 H37 N3 O6
SMILES
C[C@H]1CCC2([C@@H](C[C@H]([C@H](O2)C(C)C(=O)C3=CC=CN3)C)C)O[C@H]1CC4=NC5=C(O4)C=CC(=C5C(=O)O)NC
InChi
InChI=1S/C29H37N3O6/c1-15-10-11-29(17(3)13-16(2)27(38-29)18(4)26(33)20-7-6-12-31-20)37-22(15)14-23-32-25-21(36-23)9-8-19(30-5)24(25)28(34)35/h6-9,12,15-18,22,27,30-31H,10-11,13-14H2,1-5H3,(H,34,35)/t15-,16+,17+,18?,22-,27-,29?/m0/s1
InChiKey
HIYAVKIYRIFSCZ-CVXKHCKVSA-N
References for Calcium Ionophore A23187
References are publications that support the biological activity of the product
Role of calcium ionophore A23187-induced activation of IkappaB kinase 2 in mast cells.
Hosokawa J et al (2013)
Int Arch Allergy Immunol 161 Suppl 2 : 37-43.
Zn(2+), derived from cell preparation, partly attenuates Ca(2+)-dependent cell death induced by A23187, calcium ionophore, in rat thymocytes.
Sakanashi Y et al (2009)
Toxicol In Vitro 23(2) : 338-45.
Platelet particle formation by anti GPIIIa49-66 Ab, Ca2+ ionophore A23187, and phorbol myristate acetate is induced by reactive oxygen species and inhibited by Dex blockade of platelet phospholipase A2, 12-lipoxygenase, and NADPH oxidase.
Nardi MA et al (2007)
Blood 110(6) : 1989-96.
Publications
These publications cite the use of Calcium Ionophore A23187 purchased from Hello Bio:
Molecular Mechanisms of Synaptic Vesicle Priming by Munc13 and Munc18.
Lai et al (2017)
Neuron. 95(3) : 591-607
Non-selective calcium ionophore
![A23187 [52665-69-7] Chemical Structure](https://m2stage-v2.hellobio.com/media/catalog/product//h/b/hb1000.png "A23187 [52665-69-7]")
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