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A 967079

(HB1156)
Publications (1)

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Product overview

Name A 967079
Purity >98%
Description Potent, selective TRPA1 channel blocker
Biological Data Solubility & Handling Chemical Data Related Areas Calculators Technical guides (1) Reviews Publications (1) References (3)
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A 967079 product vial image | Hello Bio
A 967079 product vial image | Hello Bio

A 967079 product vial image | Hello Bio

A 967079 product vial image | Hello Bio

Biological Data

Biological description Potent and selective TRPA1 channel blocker (IC50 values are 67 and 289 nM for human TRPA1 and rat TRPA1 channels respectively). Exhibits greater than 1000-fold selectivity for TRPA1 over other TRP channels. Exhibits analgesic actions. Does not alter body temperature unlike other TRPV1 channel blockers.

Solubility & Handling

Storage instructions +4°C
Solubility overview Soluble in DMSO (100mM) or ethanol (100mM)
Important This product is for RESEARCH USE ONLY and is not intended for therapeutic or diagnostic use. Not for human or veterinary use.

Calculators

Molarity

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Dilution

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Chemical Data

Purity >98%
Chemical name (1E,3E)-1-(4-Fluorophenyl)-2-methyl-1-pentene-3-one oxime
Molecular Weight 207.24
Chemical structure A 967079 [1170613-55-4] Chemical Structure
Molecular Formula C12H14FNO
CAS Number 1170613-55-4
PubChem identifier 42641861
SMILES CC/C(=N\O)/C(=C/C1=CC=C(C=C1)F)/C
InChi InChI=1S/C12H14FNO/c1-3-12(14-15)9(2)8-10-4-6-11(13)7-5-10/h4-8,15H,3H2,1-2H3/b9-8+,14-12+
InChiKey HKROEBDHHKMNBZ-CHBKHGQFSA-N
MDL number MFCD20488058

References for A 967079

References are publications that support the biological activity of the product

  • TRPV1 and TRPA1 antagonists prevent the transition of acute to chronic inflammation and pain in chronic pancreatitis.

    Schwartz ES et al (2013) J Neurosci 33(13) : 5603-11.
    Read more (PubMedID: 23536075)

  • Selective blockade of TRPA1 channel attenuates pathological pain without altering noxious cold sensation or body temperature regulation.

    Chen J et al (2011) Pain 152(5) : 1165-72.
    Read more (PubMedID: 21402443)

  • TRPA1 modulation of spontaneous and mechanically evoked firing of spinal neurons in uninjured, osteoarthritic, and inflamed rats.

    McGaraughty S et al (2010) Mol Pain 6 : 14
    Read more (PubMedID: 20205719)

3 Item(s)

Publications
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These publications cite the use of A 967079 purchased from Hello Bio:

  • Distinct Mechanisms Account for In Vitro Activation and Sensitization of TRPV1 by the Porphyrin Hemin

    Palmaers NE et al (2021) Int J Mol Sci 22(19)
    PubMedID: 34639197

1 Item

Grouped product items
Order: HB1156
Pack Price Qty
5mg
$85
10mg
$122
25mg
$287
50mg
$485
Potent, selective TRPA1 channel blocker
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