The store will not work correctly when cookies are disabled.
JavaScript seems to be disabled in your browser.
For the best experience on our site, be sure to turn on Javascript in your browser.
Biological Data
Biological description
DNA methyltransferase inhibitor. Causes hypomethylation. Inhibits Wnt-β-catenin signaling pathway and improves stem cell reprogramming efficiency and induces differentiation of Mesenchymal Stem cells (MSCs) into cardiomyocytes. Shows anti-viral, anti-proliferative and anti-cancer actions.
Solubility & Handling
Storage instructions
Room temperature
Solubility overview
Soluble in water (50mM) or DMSO (100mM)
Important
This product is for RESEARCH USE ONLY and is not intended for therapeutic or diagnostic use. Not for human or veterinary use.
Chemical Data
Chemical name
4-Amino-1-β-D-ribofuranosyl-1,3,5-tr iazin-2(1H )-one
Chemical structure
Molecular Formula
C8 H12 N4 O5
SMILES
O[C@@H]1[C@H](O)[C@@H](CO)O[C@H]1N2C(N=C(N)N=C2)=O
InChiKey
NMUSYJAQQFHJEW-KVTDHHQDSA-N
References for 5-Azacytidine
References are publications that support the biological activity of the product
5-Azacytidine suppresses the proliferation of pancreatic cancer cells by inhibiting the Wnt/β-catenin signaling pathway.
Zhang H et al (2014)
Genet Mol Res 13(3) : 5064-72.
5-azacytidine reduces methylation, promotes differentiation and induces tumor regression in a patient-derived IDH1 mutant glioma xenograft.
Borodovsky A et al (2013)
Oncotarget 4(10) : 1737-47.
5-Azacytidine can induce lethal mutagenesis in human immunodeficiency virus type 1.
Dapp MJ et al (2009)
J Virol 83(22) : 11950-8.
DNA methyltransferase inhibitor. Improves stem cell reprogramming efficiency and induces differentiation of MSCs into cardiomyocytes.
![5-Azacytidine [320-67-2] Chemical Structure](https://m2stage-v2.hellobio.com/media/catalog/product//h/b/hb1374.png "5-Azacytidine [320-67-2]")
Understanding purity and quality - a guide for life scientists 
